Document Detail


Inulin and oligofructose: impact on intestinal diseases and disorders.
MedLine Citation:
PMID:  15877897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A large and diverse variety of bacteria have evolved and adapted to live in the human intestinal habitat in a symbiotic arrangement that influences both physiology and pathology in the host. Symbiosis between host and flora can be optimised by prebiotics. Inulin-type fructans have been shown to improve the metabolic functions of the commensal flora. Clinical and experimental data suggest that they also improve the gut mucosal barrier. Furthermore, modulation of the trophic functions of the flora by these prebiotics could help in the prevention of inflammatory bowel diseases. The anti-inflammatory effects of inulin or oligofructose have been assessed in the rat model of distal colitis induced by dextran sodium sulphate, which histologically resembles human ulcerative colitis, and in the trinitrobenzene sulphonic acid model that resembles human Crohn's disease. Both inulin and oligofructose stimulate colonic production of SCFA and favour the growth of indigenous lactobacilli and/or bifidobacteria. These effects are associated with reduced mucosal inflammation and decreased mucosal lesion scores. Inulin has also been tested in a placebo-controlled clinical trial in patients with relapsing pouchitis. Treatment reduced endoscopic and histological parameters of inflammation of the pouch mucosa. Inulin and oligofructose may offer an opportunity to prevent chronic inflammatory intestinal disorders, and this potential should be tested in further clinical studies.
Authors:
Francisco Guarner
Related Documents :
15307207 - Diseases of annavaha srotas (gastroenterology): historical view point.
11555437 - Geographic differences in hepatosplenic complications of schistosomiasis mansoni and ex...
21385707 - Controlling and coordinating development in vector-transmitted parasites.
12805677 - Lactococcus lactis, a tool for the delivery of therapeutic proteins treatment of ibd.
6153887 - Alveolar echinococcosis of the liver; studies on 60 operated cases.
17963677 - Epidemiology and genetics of calcific aortic valve disease.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The British journal of nutrition     Volume:  93 Suppl 1     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-05-09     Completed Date:  2005-08-08     Revised Date:  2006-04-13    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  S61-5     Citation Subset:  IM    
Affiliation:
Digestive System Research Unit, University Hospital Vall d'Hebron, Passeig Vall d'Hebron 119-129, Barcelona 08035, Spain. fguarnera@medynet.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Infections / diet therapy*,  immunology,  microbiology
Bifidobacterium
Dietary Fiber / administration & dosage*
Humans
Inflammatory Bowel Diseases / diet therapy*,  immunology,  microbiology
Intestinal Mucosa / immunology,  microbiology
Inulin / administration & dosage*
Lactobacillus
Models, Animal
Oligosaccharides / administration & dosage*
Probiotics / administration & dosage
Chemical
Reg. No./Substance:
0/Oligosaccharides; 0/oligofructose; 9005-80-5/Inulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Application of prebiotics in infant foods.
Next Document:  Mucosal bacteria in ulcerative colitis.