| Inulin and oligofructose do not influence the absorption of cholesterol, or the excretion of cholesterol, Ca, Mg, Zn, Fe, or bile acids but increases energy excretion in ileostomy subjects. | |
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MedLine Citation:
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PMID: 9023459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the effects of inulin and oligofructose on cholesterol absorption and excretion of cholesterol, bile acids, energy, nitrogen and minerals in man. DESIGN: Double-blind cross-over study. SETTING: Metabolic kitchen with policlinic visits, Sahlgrenska Hospital, Göteborg, Sweden. SUBJECTS: Patients with conventional ileostomy because of ulcerative colitis. INTERVENTIONS: 7 g of inulin, 17 g of oligofructose and 7 g of sucrose were added to a controlled diet during three experimental periods of three days each. Ileostomy effluents were collected and analysed. Differences between experimental and control diet were investigated with the Wilcoxon's sign and values test. RESULTS: Inulin and oligofructose were recovered in the ileostomy effluent to 88% (95% CI, 76-100%) and 89% (64-114%) respectively. Dry solid excretion increased by 14.4 g (11.3-17.5) on inulin, and by 14.7 g (13.0-16.4 g) on oligofructose and energy excretion increased 245 kJ (190-307 kJ) on inulin and 230 kJ (214-315 kJ) on oligofructose compared to control diet (P < 0.05). Cholesterol absorption, excretion of cholesterol, bile acids, nitrogen, fat, calcium, magnesium, zinc and iron were not affected by inulin and oligofructose. CONCLUSIONS: Inulin and oligofructose are not digested in the small intestine. They do not affect mineral excretion and hence hardly mineral absorption. They do not increase fat or nitrogen excretion from the small intestine. Any physiological effect of inulin and oligofructose is probably mediated through other mechanisms than altered excretion from the small intestine. |
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Authors:
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L Ellegård; H Andersson; I Bosaeus |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 51 ISSN: 0954-3007 ISO Abbreviation: Eur J Clin Nutr Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-04-10 Completed Date: 1997-04-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1-5 Citation Subset: IM |
Affiliation:
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Department of Clinical Nutrition, Göteborg University, Sahlgrenska Hospital, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bile Acids and Salts / metabolism* Calcium / metabolism Cholesterol / metabolism* Colitis, Ulcerative / surgery Cross-Over Studies Dietary Sucrose / administration & dosage Double-Blind Method Energy Metabolism / drug effects Female Fructose / administration & dosage, pharmacology* Humans Ileostomy* Inulin / administration & dosage, pharmacology* Iron / metabolism Magnesium / metabolism Male Middle Aged Minerals / metabolism* Zinc / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Dietary Sucrose; 0/Minerals; 30237-26-4/Fructose; 57-88-5/Cholesterol; 7439-89-6/Iron; 7439-95-4/Magnesium; 7440-66-6/Zinc; 7440-70-2/Calcium; 9005-80-5/Inulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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