Document Detail


Intussusceptive angiogenesis: pillars against the blood flow.
MedLine Citation:
PMID:  21535415     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Adaptation of vascular networks to functional demands needs vessel growth, vessel regression and vascular remodeling. Biomechanical forces resulting from blood flow play a key role in these processes. It is well-known that metabolic stimuli, mechanical forces and flow patterns can affect gene expression and remodeling of vascular networks in different ways. For instance, in the sprouting type of angiogenesis related to hypoxia, there is no blood flow in the rising capillary sprout. In contrast, it has been shown that an increase of wall shear stress initiates the splitting type of angiogenesis in skeletal muscle. Otherwise, during development, both sprouting and intussusception act in parallel in building the vascular network, although with differences in spatiotemporal distribution. Thereby, in addition to regulatory molecules, flow dynamics support the patterning and remodeling of the rising vascular tree. Herewith we present an overview of angiogenic processes with respect to intussusceptive angiogenesis as related to local hemodynamics.
Authors:
Beata Styp-Rekowska; Ruslan Hlushchuk; Axel R Pries; Valentin Djonov
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-28
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  -     ISSN:  1748-1716     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-5-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Scandinavian Physiological Society.
Affiliation:
Institute of Anatomy, University of Bern, SwitzerlandInstitute of Physiology, Charité - CBF, Berlin, GermanyHeart Center Berlin, Berlin, Germany.
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