Document Detail

Intussusception in southern Indian children: lack of association with diarrheal disease and oral polio vaccine immunization.
MedLine Citation:
PMID:  12839377     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Intussusception is the most common cause of intestinal obstruction in young children and has been reported as a complication of a recently withdrawn tetravalent reassortant rotavirus vaccine. METHODS: We studied the history, clinical presentation, management and outcome of intussusception presenting to a tertiary care hospital in southern India over a 10-year period, in order to assess potential association with diarrheal disease and immunization. RESULTS: Data from 137 index cases and 280 control subjects indicated that the risk of diarrheal disease or oral polio vaccine administration in the month prior to presentation was similar in the index cases and controls. Mean time to presentation to hospital after developing symptoms was 1.8 days, and 77.3% of patients required surgery, with 47.4% undergoing intestinal resection. Mortality was 0.006%. CONCLUSIONS: No association could be demonstrated between gastroenteritis or oral poliovirus vaccine immunization and intussusception in southern Indian children. These children presented later and required operative intervention more frequently than has been reported in other studies, but had a good outcome with low mortality.
T Raman; A Mukhopadhyaya; C E Eapen; V Aruldas; A Bose; S Sen; M K Estes; G Kang
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology     Volume:  22     ISSN:  0254-8860     ISO Abbreviation:  Indian J Gastroenterol     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-07-03     Completed Date:  2003-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8409436     Medline TA:  Indian J Gastroenterol     Country:  India    
Other Details:
Languages:  eng     Pagination:  82-4     Citation Subset:  IM    
Department of Gastrointestinal Sciences, Christian Medical College Hospital, Vellore 632 004.
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MeSH Terms
Case-Control Studies
Child Welfare
Child, Preschool
Diarrhea / epidemiology,  therapy
Ileal Diseases / epidemiology,  therapy
Ileocecal Valve*
India / epidemiology
Infant Welfare
Intussusception / epidemiology,  therapy*
Poliomyelitis / epidemiology,  therapy
Poliovirus Vaccine, Oral / administration & dosage
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Poliovirus Vaccine, Oral

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