| Introduction of a triazole amino acid into a peptoid oligomer induces turn formation in aqueous solution. | |
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MedLine Citation:
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PMID: 17506576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peptoids are a non-natural class of oligomers that are composed of repeating N-substituted glycine units and are capable of folding into helices that mimic peptide structure and function. In this letter, we report the concise synthesis of a 1,5-substituted triazole amino acid (Tzl) and its subsequent incorporation into a short peptoid. The Tzl amino acid was shown to induce turn formation in aqueous solution, thus expanding the structural repertoire available to peptoid chemists. |
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Authors:
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Jonathan K Pokorski; Lisa M Miller Jenkins; Hanqiao Feng; Stewart R Durell; Yawen Bai; Daniel H Appella |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2007-05-17 |
Journal Detail:
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Title: Organic letters Volume: 9 ISSN: 1523-7060 ISO Abbreviation: Org. Lett. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-31 Completed Date: 2007-08-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: United States |
Other Details:
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Languages: eng Pagination: 2381-3 Citation Subset: IM |
Affiliation:
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Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Models, Molecular Molecular Structure Peptoids* / analogs & derivatives, chemical synthesis, chemistry Protein Structure, Secondary Solutions / chemistry Stereoisomerism Triazoles / chemistry* Water / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Peptoids; 0/Solutions; 0/Triazoles; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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