Document Detail


Introduction of a triazole amino acid into a peptoid oligomer induces turn formation in aqueous solution.
MedLine Citation:
PMID:  17506576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peptoids are a non-natural class of oligomers that are composed of repeating N-substituted glycine units and are capable of folding into helices that mimic peptide structure and function. In this letter, we report the concise synthesis of a 1,5-substituted triazole amino acid (Tzl) and its subsequent incorporation into a short peptoid. The Tzl amino acid was shown to induce turn formation in aqueous solution, thus expanding the structural repertoire available to peptoid chemists.
Authors:
Jonathan K Pokorski; Lisa M Miller Jenkins; Hanqiao Feng; Stewart R Durell; Yawen Bai; Daniel H Appella
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2007-05-17
Journal Detail:
Title:  Organic letters     Volume:  9     ISSN:  1523-7060     ISO Abbreviation:  Org. Lett.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-31     Completed Date:  2007-08-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2381-3     Citation Subset:  IM    
Affiliation:
Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA.
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MeSH Terms
Descriptor/Qualifier:
Models, Molecular
Molecular Structure
Peptoids* / analogs & derivatives,  chemical synthesis,  chemistry
Protein Structure, Secondary
Solutions / chemistry
Stereoisomerism
Triazoles / chemistry*
Water / chemistry
Chemical
Reg. No./Substance:
0/Peptoids; 0/Solutions; 0/Triazoles; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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