Document Detail

Introduction to the biomechanics of carotid plaque pathogenesis and rupture: review of the clinical evidence.
MedLine Citation:
PMID:  20647514     Owner:  NLM     Status:  MEDLINE    
The management of patients with asymptomatic carotid disease is currently under debate and new methods are warranted for better risk stratification. The role of the biomechanical properties of the atherosclerotic arterial wall together with the effect of different stress types in plaque destabilisation has only been recently investigated. PubMed and Scopus databases were reviewed. There is preliminary clinical evidence demonstrating that the analysis of the combined effect of the various types of biomechanical stress acting on the carotid plaque may help us to identify the vulnerable plaque. At present, MRI and two-dimensional ultrasound are combined with fluid-structure interaction techniques to produce maps of the stress variation within the carotid wall, with increased cost and complexity. Stress wall analysis can be a useful tool for carotid plaque evaluation; however, further research and a multidisciplinary approach are deemed as necessary for further development in this direction.
G C Makris; A N Nicolaides; X Y Xu; G Geroulakos
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-07-20
Journal Detail:
Title:  The British journal of radiology     Volume:  83     ISSN:  1748-880X     ISO Abbreviation:  Br J Radiol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-26     Completed Date:  2011-02-03     Revised Date:  2013-03-11    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  729-35     Citation Subset:  AIM; IM    
Vascular Surgery Department, Ealing Hospital, NHS Trust, London, UK.
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MeSH Terms
Atherosclerosis / pathology*,  physiopathology
Carotid Arteries* / pathology,  physiopathology
Carotid Artery Diseases / physiopathology
Disease Progression
Endothelium, Vascular / physiopathology
Finite Element Analysis
Hemorheology / physiology
Magnetic Resonance Angiography
Rupture, Spontaneous / pathology,  physiopathology
Stress, Mechanical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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