Document Detail


Introduction to germ cell development in Caenorhabditis elegans.
MedLine Citation:
PMID:  22872472     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A central feature of the continuum of life in sexually reproducing metazoans is the cycle of the germline from one generation to the next. This volume describes the cycle of the germline for Caenorhabditis elegans through chapters that are focused on distinct aspects or processes in germ cell development. Topics include sequential and dependent processes such as specification of germ cells as distinct from somatic cells, sex determination, stem cell proliferative fate versus meiotic development decision, recombination/progression through meiotic prophase, contemporaneous processes such as gametogenesis, meiotic development and apoptosis, and continuing the cycle into the next generation through fertilization and the oocyte-to-embryo transition. Throughout germ cell development, translational control and epigenetic mechanisms play prominent roles. These different aspects of germ cell development are seamlessly integrated under optimal conditions and are modified in the different reproductive strategies that are employed by C. elegans under harsh environmental conditions. In this chapter, we set the stage by providing a brief background on the C. elegans system and germ cell development, indicating processes in the cycle of the germline that are covered in each chapter.
Authors:
Nanette Pazdernik; Tim Schedl
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  757     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-08-08     Completed Date:  2012-11-29     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-16     Citation Subset:  IM    
Affiliation:
Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. npazdernik@genetics.wustl.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Caenorhabditis elegans / cytology*,  growth & development
Germ Cells / cytology*
Grant Support
ID/Acronym/Agency:
R01 GM085150/GM/NIGMS NIH HHS; R01 GM085150/GM/NIGMS NIH HHS; T32 HD49305/HD/NICHD NIH HHS
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