Document Detail

Intrinsically radiopaque hydrogels for nucleus pulposus replacement.
MedLine Citation:
PMID:  15935467     Owner:  NLM     Status:  MEDLINE    
Degeneration of the intervertebral disc is the most common cause of back pain. In case of early stage degenerative disc disease or traumatic herniations, a suitable treatment may be to replace the nucleus pulposus, preserving the annulus fibrosus. Eight new hydrogel biomaterials were prepared and studied for their potential as a nucleus replacement. The hydrogels were designed according to the following criteria: (i), they should exhibit adequate radiopacity; (ii), they should be non-cytotoxic; (iii), implantation in the dry state and subsequent swelling in situ to fill the entire nucleus cavity; (iv), after swelling they should match the physical-mechanical properties of the native nucleus. The approach was to use copolymers consisting of 2-(4'-iodobenzoyl)-oxo-ethyl methacrylate (4IEMA) and a hydrophilic building block (either N-vinyl-2-pyrrolidinone (NVP) or 2-hydroxyethyl methacrylate (HEMA)); 4 copolymers of NVP/4IEMA and 4 copolymers of HEMA/4IEMA in different compositions (5, 10, 15 and 20 mol% 4IEMA). The study comprised 1H-NMR analysis of the copolymerization reaction NVP+4IEMA. Furthermore, the copolymers were studied with respect to their swelling behavior, mechanical properties, cytotoxicity in vitro and X-ray contrast. Hydrogels with 5 mol% 4IEMA appear to meet all criteria: they are non-cytotoxic, have adequate physical-mechanical properties and feature sufficient radiopacity in a realistic model. The potential implications of these new results with respect to treatment of degenerative disc disease are discussed briefly.
Erik J H Boelen; Catharina S J van Hooy-Corstjens; Sjoerd K Bulstra; André van Ooij; Lodewijk W van Rhijn; Leo H Koole
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomaterials     Volume:  26     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-07-26     Completed Date:  2005-10-11     Revised Date:  2012-03-22    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  6674-83     Citation Subset:  IM    
Center for Biomaterials Research, University of Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands.
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MeSH Terms
3T3 Cells
Biocompatible Materials
Cell Line
Cell Nucleus / metabolism
Glass / chemistry
Hydrogels* / chemistry
Intervertebral Disc / metabolism,  pathology*
Iodine / chemistry
Magnetic Resonance Spectroscopy
Methacrylates / chemistry
Models, Chemical
Polymers / chemistry
Stress, Mechanical
Time Factors
Reg. No./Substance:
0/Biocompatible Materials; 0/Hydrogels; 0/Methacrylates; 0/Polymers; 7553-56-2/Iodine; 868-77-9/hydroxyethyl methacrylate

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