| Intrinsic vasodilation protects Wistar Kyoto rats from progressive glomerulosclerosis after unilateral nephrectomy. | |
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MedLine Citation:
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PMID: 1987305 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genetically determined differences in functional and structural determinants that govern the development of progressive glomerulosclerosis (GS) were studied in aging sham-operated or unilaterally nephrectomized male rats of two strains. Wistar rats showed an increase of proteinuria and GS with age, which was enhanced by unilateral nephrectomy (UN). In contrast, intact and UN Wistar Kyoto rats did not show an increase of proteinuria with age and 7 months after UN, no GS was seen in these rats. Systemic blood pressure was comparable in both strains and was not affected by UN. Functional studies in a separate group of rats 1 month after UN showed an identical increase in glomerular filtration rate in both strains as compared with sham-operated controls. The Wistar rats did not show an effect of UN on renal plasma flow, and consequently, there was an increase in filtration fraction, in contrast to Wistar Kyoto rats, which showed an increase in renal plasma flow with an unchanged filtration fraction. Glomerular volume was increased in both strains at 1 month and 7 months after UN. Mesangial expansion was not observed at 1 month after UN in either strain, which indicates that this is not a decisive factor in the development of GS. These data indicate that the genetically determined susceptibility to the development of GS in these two rat strains may be related to the degree of vasoconstriction, whereas glomerular volume expansion per se does not lead to GS but can well be a consequence of hyperfiltration. These studies are concordant with previous studies that revealed the role of hemodynamics in the pathogenesis of GS irrespective of glomerular expansion. |
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Authors:
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P J Westenend; Y A Nooyen; P van Brummelen; J J Weening |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of laboratory and clinical medicine Volume: 117 ISSN: 0022-2143 ISO Abbreviation: J. Lab. Clin. Med. Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-02-15 Completed Date: 1991-02-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375375 Medline TA: J Lab Clin Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 25-32 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, State University of Leiden, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Glomerulonephritis / pathology* Hemodynamics Kidney Diseases / etiology, prevention & control Kidney Glomerulus / pathology* Nephrectomy* / methods Rats Rats, Inbred Strains Rats, Inbred WKY / physiology* Sclerosis Time Factors Vasodilation* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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