| Intrinsic tumor biomarkers revealed by novel double-differential spectroscopic analysis of near-infrared spectra. | |
| | |
MedLine Citation:
|
PMID: 17477706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We develop a double-differential spectroscopic analysis method for broadband near-infrared (NIR, 650 to 1000 nm) absorption spectra. Application of this method to spectra of tumor-containing breast tissue reveals specific cancer biomarkers. In this method, patient-specific variations in molecular composition are removed by using the normal tissue as an internal control. The effects of concentration differences of the four major tissue absorbers (oxyhemoglobin, deoxyhemoglobin, water, and bulk lipid) between the tumor and normal tissue are accounted for to reveal small spectral components unique to cancer. From a pilot study of 15 cancer patients, we find these spectral components to be characterized by specific NIR absorption bands. Based on the spectral regions of absorption at about 760, 930, and 980 nm, we identify these biomarkers with changes in state or addition of lipid and/or water. To quantify spectral variation in the absorption bands, we construct the specific tumor component (STC) index. The STC index identifies regions of the breast with tumors. |
| | |
Authors:
|
Shwayta Kukreti; Albert Cerussi; Bruce Tromberg; Enrico Gratton |
Related Documents
:
|
15782996 - Histochemical expression of sialoglycoconjugates in carcinoma of the papilla of vater. 22661056 - Differential diagnosis of sclerosing cholangitis with autoimmune pancreatitis and perid... 3815386 - Characterization of glycolipids from the gastric cancer of a patient of p,o,le(a-,b+) b... 2394856 - Cutaneous phaeohyphomycosis caused by a rare fungal pathogen, hormonema dematioides: su... 23448806 - Breast cancer survivors of different sexual orientations: which factors explain survivo... 17004426 - Factors associated with delays in screening of self-detected breast changes in african-... |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Journal of biomedical optics Volume: 12 ISSN: 1083-3668 ISO Abbreviation: J Biomed Opt Publication Date: 2007 Mar-Apr |
Date Detail:
|
Created Date: 2007-05-04 Completed Date: 2007-07-11 Revised Date: 2007-12-03 |
Medline Journal Info:
|
Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
|
Languages: eng Pagination: 020509 Citation Subset: IM |
Affiliation:
|
University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Algorithms* Breast Neoplasms / diagnosis*, metabolism* Diagnosis, Computer-Assisted / methods* Humans Neoplasm Proteins / analysis* Spectrophotometry, Infrared / methods* Tumor Cells, Cultured Tumor Markers, Biological / analysis* |
| Grant Support | |
ID/Acronym/Agency:
|
P30-CA62203/CA/NCI NIH HHS; P41-RR01192/RR/NCRR NIH HHS; P41-RR03155/RR/NCRR NIH HHS; R01 EB00559/EB/NIBIB NIH HHS; U54-CA105480-01/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Neoplasm Proteins; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Portable two-color in vivo flow cytometer for real-time detection of fluorescently-labeled circulati...
Next Document: Suppression of ultrafast supercontinuum generation in a salivary protein.