| Intrinsic pump-conduit behavior of lymphangions. | |
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MedLine Citation:
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PMID: 17122333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lymphangions, segments of lymphatic vessels bounded by valves, have characteristics of both ventricles and arteries. They can act primarily like pumps when actively transporting lymph against a pressure gradient. They also can act as conduit vessels when passively transporting lymph down a pressure gradient. This duality has implications for clinical treatment of several types of edema, since the strategy to optimize lymph flow may depend on whether it is most beneficial for lymphangions to act as pumps or conduits. To address this duality, we employed a simple computational model of a contracting lymphangion, predicted the flows at both positive and negative axial pressure gradients, and validated the results with in vitro experiments on bovine mesenteric vessels. This model illustrates that contraction increases flow for normal axial pressure gradients. With edema, limb elevation, or external compression, however, the pressure gradient might reverse, and lymph may flow passively down a pressure gradient. In such cases, the valves may be forced open during the entire contraction cycle. The vessel thus acts as a conduit, and contraction has the effect of increasing resistance to passive flow, thus inhibiting flow rather than promoting it. This analysis may explain a possible physiological benefit of the observed flow-mediated inhibition of the lymphatic pump at high flow rates. |
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Authors:
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Christopher M Quick; Arun M Venugopal; Anatoliy A Gashev; David C Zawieja; Randolph H Stewart |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-11-22 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 292 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-04 Completed Date: 2007-05-23 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R1510-8 Citation Subset: IM |
Affiliation:
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College of Veterinary Medicine, 4466 Texas A and M University, College Station, TX 77843-4466, USA. cquick@tamu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Buffers Cattle Computational Biology Computer Simulation Hydrogen-Ion Concentration Lymph / physiology* Lymphatic System / physiology* Mesentery Models, Theoretical Muscle Contraction Muscle, Smooth / physiology Perfusion Pressure Temperature |
| Grant Support | |
ID/Acronym/Agency:
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HL-070608/HL/NHLBI NIH HHS; HL-07688/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Buffers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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