Document Detail


Intrinsic physiology of identified neurons in the prepositus hypoglossi and medial vestibular nuclei.
MedLine Citation:
PMID:  21422541     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Signal processing in the vestibular system is influenced by the intrinsic physiological properties of neurons that differ in neurotransmitters and circuit connections. Do membrane and firing properties differ across functionally distinct cell types? This study examines the intrinsic physiology of neurons in the medial vestibular nucleus (MVN) and nucleus prepositus hypoglossi (NPH) which express different neurotransmitters and have distinct axonal projections. NPH neurons expressing fluorescent proteins in glutamatergic, glycinergic, or GABAergic neurons were targeted for whole-cell patch recordings in brainstem slices obtained from transgenic mouse lines (YFP-16, GlyT2, and GIN). Recordings from MVN neurons projecting to the spinal cord, reticular formation, or oculomotor nucleus were obtained by targeting fluorescent neurons retrogradely labeled from tracer injections. Intrinsic physiological properties of identified neurons exhibited continuous variations but tended to differ between functionally defined cell types. Within the NPH, YFP-16 neurons had the narrowest action potentials and highest evoked firing rates and expressed high levels of Kv3.3 proteins, which speed repolarization. MVN neurons projecting to the spinal cord and oculomotor nucleus had similar action potential waveforms, but oculomotor-projecting neurons had higher intrinsic gains than those projecting to the spinal cord. These results indicate that intrinsic membrane properties are differentially tuned in MVN and NPH neurons subserving different functions.
Authors:
Kristine E Kolkman; Setareh H Moghadam; Sascha du Lac
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of vestibular research : equilibrium & orientation     Volume:  21     ISSN:  1878-6464     ISO Abbreviation:  J Vestib Res     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-08-01     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  9104163     Medline TA:  J Vestib Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  33-47     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology*
Animals
Medulla Oblongata / cytology,  physiology*
Mice
Mice, Transgenic
Neurons / physiology*
Reflex, Vestibulo-Ocular / physiology
Vestibular Nuclei / cytology,  physiology*
Grant Support
ID/Acronym/Agency:
EY11027/EY/NEI NIH HHS; R01 EY011027/EY/NEI NIH HHS; R01 EY011027-14/EY/NEI NIH HHS; R01 EY011027-15/EY/NEI NIH HHS; //Howard Hughes Medical Institute
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