Document Detail

Intrinsic noise and Hill dynamics in the p53 system.
MedLine Citation:
PMID:  20974153     Owner:  NLM     Status:  In-Data-Review    
The p53 feedback loop can induce cellular senescence, cell cycle arrest and apoptosis in response to various stresses, including DNA damage, hypoxia and nutrient deprivation. Using a stochastic model of the negative feedback circuit involving p53 and its inhibitor Mdm2, we present the different oscillatory dynamics at the single-cell and population-cell levels as described in the experiments, and the resonant nature of the oscillations is captured. The stationary distributions of protein populations are characterized by non-Gaussian nature which is due to the interplay between time delay and nonlinearity of reactions.
Bo Liu; Shiwei Yan; Qi Wang
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Publication Detail:
Type:  Journal Article     Date:  2010-10-23
Journal Detail:
Title:  Journal of theoretical biology     Volume:  269     ISSN:  1095-8541     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  104-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
College of Nuclear Science and Technology, Beijing Normal University, Beijing 100875, China.
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