Document Detail

Intrinsic lymphatic partition rate of mepitiostane, epitiostanol, and oleic acid absorbed from rat intestine.
MedLine Citation:
PMID:  1796049     Owner:  NLM     Status:  MEDLINE    
Mepitiostane (MP), epitiostanol (EP), and oleic acid were administered to the jejunal loop of mesenteric vein- and thoracic duct-cannulated rats, and the intrinsic lymphatic partition rate (ILPR) of the absorbed compounds was directly determined. When 14C-EP was administered to the jejunal loop, recovery of unchanged EP in the mesenteric blood and the lymph was 7.9 and 0.03% of the administered dose, respectively. In contrast, following administration of 14C-MP, recovery of unchanged MP in the mesenteric blood and the lymph was 1.2 and 15.0%, respectively. Thus, following passage through the mucosal cell, 99.6% of the unchanged EP was partitioned into the blood and 0.4% into the lymph, while for unchanged MP, 7.6% was partitioned into the blood and 92.4% into the lymph. When 14C-oleic acid was administered to the jejunal loop, most of the penetrating oleic acid was incorporated into triglycerides in epithelial cells and transferred exclusively into the lymph. However, of the unchanged oleic acid, only 37.6% was partitioned into the lymph and 62.4% into the blood. The ILPR was 92.4% for MP, 0.4% for EP, and 37.6% for oleic acid. We conclude that the ILPR values indicate the true lymphotropic property of the compounds.
T Ichihashi; H Kinoshita; Y Takagishi; H Yamada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmaceutical research     Volume:  8     ISSN:  0724-8741     ISO Abbreviation:  Pharm. Res.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-04-08     Completed Date:  1992-04-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1302-6     Citation Subset:  IM    
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
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MeSH Terms
Androstanols / blood,  pharmacokinetics*
Bile Ducts / physiology
Intestinal Absorption*
Lymph / metabolism
Lymphatic System / metabolism*
Mesenteric Veins / metabolism
Oleic Acid
Oleic Acids / blood,  pharmacokinetics*
Rats, Inbred Strains
Reg. No./Substance:
0/Androstanols; 0/Oleic Acids; 112-80-1/Oleic Acid; 21362-69-6/mepitiostane; 2363-58-8/epitiostanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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