Document Detail


Intrinsic fluorescence polarization of amniotic fluid: II. Toward a noninvasive method for the determination of fetal lung maturity.
MedLine Citation:
PMID:  16961437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study compares two methods for the determination of fetal lung maturity: the novel intrinsic fluorescence polarization ratio (IFPR) and the commercial TDx-FLMII. Amniotic fluid (AF) samples were collected from 69 women during the second and third trimesters of singleton pregnancies. Thirty-three samples were tested for IFPR only after centrifugation, and the rest were examined both before and after centrifugation. Of the latter 33 samples, 29 were assessed for lung maturity with the TDx-FLMII method as well. The results showed that IFPR values decreased with the advance in gestational age (r = 0.77, p < 0.05, n = 69). A significant correlation was found between IFPR of centrifuged and noncentrifuged samples (r = 0.94, p < 0.05, n = 36). A significant correlation was demonstrated between IFPR and TDx-FLMII values of centrifuged (r = 0.75, p < 0.05, n = 29) and noncentrifuged (r = 0.63, p < 0.05, n = 29) samples and moreover, samples considered mature by TDx-FLMII had low values of IFPR (n = 10). It can be concluded that the IFPR method can utilize noncentrifuged AF, thus suggested as a potential noninvasive method.
Authors:
Hemy Avraham; Eric Ohana; Eli Maymon; Rivka Cohen-Luria; Jonathan Molcho; Abraham H Parola
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  82     ISSN:  0031-8655     ISO Abbreviation:  Photochem. Photobiol.     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2007-03-26     Completed Date:  2007-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1591-4     Citation Subset:  IM    
Affiliation:
Department of Electrical and Computer Engineering, Faculty of Engineering Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
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MeSH Terms
Descriptor/Qualifier:
Amniotic Fluid / chemistry*
Female
Fluorescence Polarization
Gestational Age
Humans
Infant, Newborn
Pregnancy
Pregnancy Trimester, Second
Pregnancy Trimester, Third

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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