| Intrinsic control of sodium excretion in the distal nephron by inhibitory purinergic regulation of the epithelial Na+ channel. | |
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MedLine Citation:
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PMID: 22143248 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: This review summarizes the new evidence for an intrinsic control system in the aldosterone-sensitive distal nephron in which purinergic signaling regulates sodium transport and governs renal sodium excretion. RECENT FINDINGS: Electrophysiological studies identify epithelial Na channels (ENaC) as final effectors of purinergic signaling via P2Y2 receptors in the distal nephron. Inhibition of ENaC by autocrine/paracrine purinergic signaling reduces sodium reabsorption allowing an appropriately graded pressure-natriuresis response when delivery of sodium to the distal nephron is high. Disruption of this intrinsic control mechanism decreases sodium excretion and therefore has a prohypertensive effect. Because purinergic inhibition of ENaC is tonic yet submaximal, its enhancement increases sodium excretion and therefore has an antihypertensive action. SUMMARY: Purinergic inhibitory regulation of ENaC is a key component of an intrinsic control system that enables the distal nephron to respond appropriately to the delivered load of sodium. This control system is physiologically important and functions in parallel with extrinsic control by the renin-angiotensin-aldosterone system, enabling sodium excretion to keep pace with sodium intake, especially when intake is high, and thereby maintaining arterial blood pressure. Disruption of intrinsic control of sodium transport by the distal nephron likely contributes to diseases such as arterial hypertension. |
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Authors:
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Glenn M Toney; Volker Vallon; James D Stockand |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in nephrology and hypertension Volume: 21 ISSN: 1535-3842 ISO Abbreviation: Curr. Opin. Nephrol. Hypertens. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9303753 Medline TA: Curr Opin Nephrol Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 52-60 Citation Subset: IM |
Affiliation:
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aDepartment of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas bDepartment of Medicine cDepartment of Pharmacology, University of California San Diego dVA San Diego Healthcare System, San Diego, California, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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