Document Detail

Intrinsic circadian period of adolescent humans measured in conditions of forced desynchrony.
MedLine Citation:
PMID:  10025716     Owner:  NLM     Status:  MEDLINE    
Circadian timing was assessed with forced desynchrony (FD) in 10 healthy adolescents (five boys, five girls; mean age 13.7 years). Following 10 days of entrainment to a fixed light-dark (LD) schedule at home, participants were studied under dim light (<20 lux) in the laboratory. A 28-h schedule (FD) was imposed for 12 x 28-h cycles. Saliva was collected at 30- or 60-min intervals throughout; core temperature was measured in constant routines (CR) before and after FD. Intrinsic circadian period was estimated by linear regression using temperature minimum from CRs and dim-light salivary melatonin onsets and offsets from FD. Average intrinsic circadian period for core temperature (n = 7) was 24.30+/-0.20, for melatonin onset was 24.33+/-0.21, and for melatonin offset was 24.35+/-0.21. Intrinsic circadian period in every adolescent was greater than 24 h.
M A Carskadon; S E Labyak; C Acebo; R Seifer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  260     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-06-18     Completed Date:  1999-06-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  129-32     Citation Subset:  IM    
Chronobiology and Sleep Research Laboratory, E.P. Bradley Hospital, E. Providence, RI 02915, USA.
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MeSH Terms
Body Temperature / physiology
Circadian Rhythm / physiology*
Melatonin / analysis
Saliva / chemistry,  physiology
Grant Support
Reg. No./Substance:

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