| Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes. | |
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MedLine Citation:
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PMID: 20883967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A wide range of microorganisms can replicate in macrophages, and cell entry of these pathogens via non-neutralising IgG antibody complexes can result in increased intracellular infection through idiosyncratic Fcγ-receptor signalling. The activation of Fcγ receptors usually leads to phagocytosis. Paradoxically, the ligation of monocyte or macrophage Fcγ receptors by IgG immune complexes, rather than aiding host defences, can suppress innate immunity, increase production of interleukin 10, and bias T-helper-1 (Th1) responses to Th2 responses, leading to increased infectious output by infected cells. This intrinsic antibody-dependent enhancement (ADE) of infection modulates the severity of diseases as disparate as dengue haemorrhagic fever and leishmaniasis. Intrinsic ADE is distinct from extrinsic ADE, whereby complexes of infectious agents with non-neutralising antibodies lead to an increased number of infected cells. Intrinsic ADE might be involved in many protozoan, bacterial, and viral infections. We review insights into intracellular mechanisms and implications of enhanced pathogenesis after ligation of macrophage Fcγ receptors by infectious immune complexes. |
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Authors:
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Scott B Halstead; Suresh Mahalingam; Mary A Marovich; Sukathida Ubol; David M Mosser |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Lancet infectious diseases Volume: 10 ISSN: 1474-4457 ISO Abbreviation: Lancet Infect Dis Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-10-19 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101130150 Medline TA: Lancet Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 712-22 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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International Vaccine Institute, Seoul, Korea. halsteads@erols.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibody-Dependent Enhancement* Antigen-Antibody Complex / metabolism* Bacteria / immunology*, pathogenicity Eukaryota / immunology*, pathogenicity Humans Immunoglobulin G / immunology* Macrophages / immunology, microbiology* Monocytes / immunology, microbiology Receptors, IgG / immunology Th1 Cells / immunology Th2 Cells / immunology Viruses / immunology*, pathogenicity |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI049383-10/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigen-Antibody Complex; 0/Immunoglobulin G; 0/Receptors, IgG |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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