| Intravitreal triamcinolone versus bevacizumab for treatment of refractory diabetic macular oedema (IBEME study). | |
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MedLine Citation:
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PMID: 17965109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: The aim of this study was to compare the morphological and visual acuity outcomes associated with a single intravitreal injection of triamcinolone acetonide versus bevacizumab for the treatment of refractory diffuse diabetic macular oedema. METHODS: Twenty-eight patients were randomly assigned to receive a single intravitreal injection of either 4 mg/0.1 ml triamcinolone acetonide or 1.5 mg/0.06 ml bevacizumab. Comprehensive ophthalmic evaluation was performed at baseline and at weeks 1, 4, 8 (+/-1), 12 (+/-2) and 24 (+/-2) after treatment. Main outcome measures included central macular thickness measured with optical coherence tomography (OCT) and best corrected Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity. RESULTS: Twenty-six patients (26 eyes) completed all study visits (two patients missed two consecutive study visits). Central macular thickness was significantly reduced in the intravitreal triamcinolone group compared with the bevacizumab group at weeks 4, 8, 12 and 24 (p<0.05). Logarithm of the minimum angle of resolution (LogMAR) best-corrected visual acuity was significantly higher at weeks 8 (0.69; approximately 20/100(+1)) and 12 (0.74; 20/100(-2)) in the intravitreal triamcinolone group compared with the bevacizumab group (weeks 8 (0.83; approximately 20/125(-1)) and 12 (0.86; 20/160(+2))) (p<0.05). Significant change from baseline in mean intraocular pressure (mmHg) was seen at week 4 (+2.25) only in the intravitreal triamcinolone group (p<0.0001). No patient had observed cataract progression during the study. CONCLUSIONS: One single intravitreal injection of triamcinolone may offer certain advantages over bevacizumab in the short-term management of refractory diabetic macular oedema, specifically with regard to changes in central macular thickness. The actual clinical relevance of our preliminary findings, however, remains to be determined in future larger studies. |
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Authors:
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L Paccola; R A Costa; M S Folgosa; J C Barbosa; I U Scott; R Jorge |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2007-10-26 |
Journal Detail:
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Title: The British journal of ophthalmology Volume: 92 ISSN: 1468-2079 ISO Abbreviation: Br J Ophthalmol Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-24 Completed Date: 2008-01-18 Revised Date: 2008-05-28 |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: England |
Other Details:
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Languages: eng Pagination: 76-80 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, School of Medicine of Ribeirão Preto, Ribeirão Preto, SP, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiogenesis Inhibitors / therapeutic use Antibodies, Monoclonal / therapeutic use* Diabetic Retinopathy / drug therapy*, pathology, physiopathology Female Follow-Up Studies Glucocorticoids / therapeutic use Humans Immunosuppressive Agents / therapeutic use Injections Intraocular Pressure / drug effects Macular Edema / drug therapy*, pathology, physiopathology Male Middle Aged Prospective Studies Tomography, Optical Coherence Treatment Outcome Triamcinolone Acetonide / therapeutic use* Visual Acuity / drug effects Vitreous Body |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal; 0/Glucocorticoids; 0/Immunosuppressive Agents; 0/bevacizumab; 76-25-5/Triamcinolone Acetonide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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