Document Detail


Intravitreal triamcinolone acetonide treatment of macular edema associated with central retinal vein occlusion.
MedLine Citation:
PMID:  17031289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate treatment of macular edema associated with central retinal vein occlusion (CRVO) using intravitreal triamcinolone acetonide. METHODS: Retrospective review of data for 29 eyes of 29 patients with CRVO and macular edema treated with intravitreal triamcinolone acetonide. Initial visual acuity, intraocular pressure, and history of glaucoma were recorded. Final visual acuity, intraocular pressure, and adverse events were recorded during the treatment period. RESULTS: Twenty-nine eyes were treated with intravitreal injection. The mean follow-up was 348 days. The median initial Early Treatment Diabetic Retinopathy Study visual acuity was 20/250 (median logMAR, 1.1). The median visual acuity 3 months after injection was 20/125 (median logMAR, 0.8). This difference was statistically significant. The median final visual acuity was 20/250 (median logMAR, 1.1). This difference in visual acuity was not statistically significant. Elevated intraocular pressure, excluding that related to neovascularization, occurred in 5 of 22 patients. Subgroup analysis revealed that patients who received multiple injections had better outcomes. CONCLUSION: Intravitreal triamcinolone acetonide may improve vision transiently but does not appear to result in a sustained visual acuity benefit for patients with macular edema associated with CRVO. Repeated injections may be necessary. The risk of glaucoma is significant, and additional study is required to further characterize this and other risks.
Authors:
Mitchell J Goff; J Michael Jumper; Sam S Yang; Arthur D Fu; Robert N Johnson; H Richard McDonald; Everett Ai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Retina (Philadelphia, Pa.)     Volume:  26     ISSN:  0275-004X     ISO Abbreviation:  Retina (Philadelphia, Pa.)     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-10     Completed Date:  2006-11-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8309919     Medline TA:  Retina     Country:  United States    
Other Details:
Languages:  eng     Pagination:  896-901     Citation Subset:  IM    
Affiliation:
Pacific Vision Foundation, California Pacific Medical Center, San Francisco, California, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Female
Glaucoma / chemically induced
Glucocorticoids / adverse effects,  therapeutic use*
Humans
Injections
Intraocular Pressure / drug effects
Macular Edema / diagnosis,  drug therapy*,  etiology
Male
Middle Aged
Retinal Vein Occlusion / complications*,  diagnosis
Retrospective Studies
Treatment Outcome
Triamcinolone Acetonide / adverse effects,  therapeutic use*
Visual Acuity / drug effects
Vitreous Body
Chemical
Reg. No./Substance:
0/Glucocorticoids; 76-25-5/Triamcinolone Acetonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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