Document Detail

Intravitreal ranibizumab in retinal macroaneurysm.
MedLine Citation:
PMID:  20508944     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To present the effect of intravitreal ranibizumab (Lucentis®) therapy in a patient suffering from retinal macroaneurysm.
METHODS: Case report. An 82-year-old female patient was diagnosed with retinal macroaneurysm of the inferior temporal artery with macular edema. Functional and morphological data at baseline and at 4 weeks, 3 months, and 5 months after the initiation of therapy with two intravitreal ranibizumab (Lucentis®) injections followed by focal argon laser coagulation surrounding the retinal macroaneurysm are presented.
RESULTS: Best-corrected visual acuity improved from 20/50 at baseline to 20/20 at 3-month follow-up and maintained stable at 20/25 through 5-month follow-up. Central retinal thickness measured by optical coherence tomography decreased from 510 µm at baseline to 148 µm at 5-month follow-up. Fluorescein angiography demonstrated closure of the retinal macroaneurysm at 6-week follow-up. No ocular or systemic side effects were detected.
CONCLUSIONS: Intravitreal ranibizumab (Lucentis®) therapy may close the retinal macroaneurysm leading to resolution of the associated macular edema and consequently visual improvement. To our knowledge, this is the first case of a retinal macroaneurysm benefiting from treatment with intravitreal ranibizumab (Lucentis®). The observed results warrant further investigation.
Andrea R Wenkstern; Heike Petersen
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-05-28
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  248     ISSN:  1435-702X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-24     Completed Date:  2010-12-22     Revised Date:  2011-09-20    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1667-70     Citation Subset:  IM    
Eye Center Uzwil, Uzwil, Switzerland.
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MeSH Terms
Aged, 80 and over
Aneurysm / diagnosis,  drug therapy*
Antibodies, Monoclonal / administration & dosage*
Fluorescein Angiography
Follow-Up Studies
Intravitreal Injections
Laser Coagulation
Off-Label Use
Retinal Diseases / diagnosis,  drug therapy*
Retinal Vessels / drug effects*,  pathology
Visual Acuity / physiology
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/ranibizumab
Comment In:
Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1267-8   [PMID:  20953619 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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