Document Detail


Intravitreal ranibizumab as an adjunct for ahmed valve surgery in open angle glaucoma: a pilot study1.
MedLine Citation:
PMID:  22712537     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:  To determine the safety and efficacy of intravitreal ranibizumab therapy before and after Ahmed tube insertion for open angle glaucoma (OAG) as a means of optimizing postoperative intraocular pressure (IOP) control. Design:  randomized, controlled trial Participants:  OAG patients scheduled for Ahmed tube insertion, randomized to ranibizumab or control groups Methods:  Ranibizumab (0.5 mg in 0.05 ml) was administered intravitreally at 3 time points: 9 days prior to surgery, 1 month post-surgery, and 2 months post-surgery. Control patients underwent the same procedure without ranibizumab. Main Outcome Measure:  Success at 6 months postoperatively was defined as IOP < 18 mmHg with no adjunctive medications, or IOP < 15 mmHg with one adjunctive medication. Results:  The study and control arms included 6 and 5 subjects, respectively, with 4 in each arm undergoing combined cataract surgery. In the ranibizumab arm, the pre- and postoperative IOP/medication usage was 21.0 ± 6.7 mmHg on 3.2 ± 1.5 medications and 14.7 ± 1.9 mmHg on 0.5 ± 0.8 medications, respectively. In the control arm, pre- and postoperative IOP/medication usage was 18.8 ± 3.8 mmHg on 2.8 ± 1.3 medications and 16.2 ± 3.6 mmHg with 1.8 ± 1.6 medications, respectively. Success was achieved in 83% of subjects in the ranibizumab group compared to 40% in the control group (2-tailed Fisher's exact test, p = 0.24). Conclusion:  The findings from this small pilot comparative study suggest that intravitreal ranibizumab use may be a safe and potentially effective adjunctive treatment modality in improving success after Ahmed tube placement. © 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists.
Authors:
Rajen U Desai; Kuldev Singh; And Shan C Lin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-19
Journal Detail:
Title:  Clinical & experimental ophthalmology     Volume:  -     ISSN:  1442-9071     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896531     Medline TA:  Clin Experiment Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists.
Affiliation:
Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA Department of Ophthalmology, Stanford University School of Medicine, CA, USA.
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