Document Detail

Intravitreal ranibizumab as an adjunct for ahmed valve surgery in open angle glaucoma: a pilot study1.
MedLine Citation:
PMID:  22712537     Owner:  NLM     Status:  Publisher    
Background:  To determine the safety and efficacy of intravitreal ranibizumab therapy before and after Ahmed tube insertion for open angle glaucoma (OAG) as a means of optimizing postoperative intraocular pressure (IOP) control. Design:  randomized, controlled trial Participants:  OAG patients scheduled for Ahmed tube insertion, randomized to ranibizumab or control groups Methods:  Ranibizumab (0.5 mg in 0.05 ml) was administered intravitreally at 3 time points: 9 days prior to surgery, 1 month post-surgery, and 2 months post-surgery. Control patients underwent the same procedure without ranibizumab. Main Outcome Measure:  Success at 6 months postoperatively was defined as IOP < 18 mmHg with no adjunctive medications, or IOP < 15 mmHg with one adjunctive medication. Results:  The study and control arms included 6 and 5 subjects, respectively, with 4 in each arm undergoing combined cataract surgery. In the ranibizumab arm, the pre- and postoperative IOP/medication usage was 21.0 ± 6.7 mmHg on 3.2 ± 1.5 medications and 14.7 ± 1.9 mmHg on 0.5 ± 0.8 medications, respectively. In the control arm, pre- and postoperative IOP/medication usage was 18.8 ± 3.8 mmHg on 2.8 ± 1.3 medications and 16.2 ± 3.6 mmHg with 1.8 ± 1.6 medications, respectively. Success was achieved in 83% of subjects in the ranibizumab group compared to 40% in the control group (2-tailed Fisher's exact test, p = 0.24). Conclusion:  The findings from this small pilot comparative study suggest that intravitreal ranibizumab use may be a safe and potentially effective adjunctive treatment modality in improving success after Ahmed tube placement. © 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists.
Rajen U Desai; Kuldev Singh; And Shan C Lin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-19
Journal Detail:
Title:  Clinical & experimental ophthalmology     Volume:  -     ISSN:  1442-9071     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896531     Medline TA:  Clin Experiment Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists.
Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA Department of Ophthalmology, Stanford University School of Medicine, CA, USA.
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