Document Detail

Intravitreal erythropoietin injection for the treatment of non-arteritic anterior ischaemic optic neuropathy.
MedLine Citation:
PMID:  21131378     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the effect of intravitreal injection of erythropoietin for the treatment of non-arteritic anterior ischaemic optic neuropathy (NAION).
METHODS: In this prospective interventional case series, 31 eyes of 31 patients with NAION were included. Patients received intravitreal injection of 2000 unit (0.2 cm³) of erythropoietin within 1 month of the onset of the disease. Visual acuity and visual field were recorded before injections and 1 week, 1 month, 3 months and 6 months after the injections.
RESULTS: The mean duration of symptoms before injections was 11.2 ± 5.5 days. Six months after injections, visual acuity improved in 27 eyes (87%), and 17 eyes (54.8%) had ≥ 3 lines of visual improvement. The mean preinjection visual acuity was 1.01 ± 0.88 logMAR and 0.58 ± 0.58 logMAR (p<0.001) at last follow-up. Visual acuity improvement occurred in 61.2% of patients within the first month. It followed a biphasic pattern in which there was continuous improvement up to 3 months and then started to deteriorate, although it remained significantly better than baseline until the last follow-up. No patient lost any lines of visual acuity compared with the baseline values. The mean of mean deviations of visual field was -19.6 ± 5.7 dB at baseline and -18.6 ± 6.3 dB (p = 0.6) at last follow-up.
CONCLUSIONS: Intravitreal injection of erythropoietin may be safe and effective in the treatment of NAION. The effect may last for a few months and then decline.
Mehdi Modarres; Khalil Ghasemi Falavarjani; Hossein Nazari; Mostafa Soltan Sanjari; Farzaneh Aghamohammadi; Mohsen Homaii; Nasrollah Samiy
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Publication Detail:
Type:  Journal Article     Date:  2010-12-03
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  95     ISSN:  1468-2079     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-20     Completed Date:  2011-08-12     Revised Date:  2011-11-30    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  992-5     Citation Subset:  IM    
Eye Research Center, Rassoul Akram Hospital, Tehran 14455-364, Iran.
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MeSH Terms
Cohort Studies
Erythropoietin / therapeutic use*
Intravitreal Injections
Macular Edema / drug therapy*
Middle Aged
Optic Neuropathy, Ischemic / drug therapy*,  physiopathology
Prospective Studies
Tomography, Optical Coherence
Treatment Outcome
Visual Acuity / drug effects*,  physiology
Visual Field Tests
Reg. No./Substance:
Comment In:
Br J Ophthalmol. 2011 Nov;95(11):1617-8   [PMID:  21951569 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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