Document Detail


Intravitreal dexamethasone implant (Ozurdex) for macular edema secondary to retinitis pigmentosa.
MedLine Citation:
PMID:  23275039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: To evaluate the anatomical and functional outcomes of intravitreal dexamethasone implant in patients with macular edema (ME) secondary to retinitis pigmentosa (RP).
METHODS: Three patients (four eyes), aged 24 to 46 years, presented with refractory ME secondary to RP. Intravitreal dexamethasone implant (Ozurdex) was administered to treat ME. The anatomical (central macular thickness [CMT]) and functional (best-corrected visual acuity [BCVA]) outcomes as well as adverse events were recorded.
RESULTS: All patients completed 6 months follow-up. After intravitreal Ozurdex all patients showed regression of ME. At baseline, mean CMT was 443 ± 185 μm (range 213-619 μm); ME improved to 234 ± 68 μm (range 142-307 μm) at 1 month, to 332 ± 177 μm (range 139-513 μm) at 3 months, and to 305 ± 124 μm (range 144-447 μm) at 6 months. Recurrent ME was recorded in 2 patients (both patients at 3 months from intravitreal dexamethasone implant). Retreatment with intravitreal Ozurdex was performed in two patients. Mean BCVA improved form 20/160 (range 20/50-20/200) (baseline) to 20/100 (range 20/40-20/125) at 1 month, to ∼20/125 (range 20/100-20/200) at 3 months, and to ∼ 20/125 (range 20/100-20/160) at 6 months. No serious ocular and systemic adverse events were observed during the study period.
CONCLUSIONS: Intravitreal dexamethasone implant provides anatomic and functional improvements and may represent a valuable treatment option for patients with ME secondary to RP.
Authors:
Mayer Srour; Giuseppe Querques; Nicolas Leveziel; Jennyfer Zerbib; Julien Tilleul; Elise Boulanger-Scemama; Eric H Souied
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2012-12-29
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  251     ISSN:  1435-702X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-24     Completed Date:  2013-11-06     Revised Date:  2014-01-29    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1501-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Dexamethasone / administration & dosage*
Drug Implants
Female
Follow-Up Studies
Glucocorticoids / administration & dosage*
Humans
Macular Edema / drug therapy*,  etiology,  physiopathology
Male
Middle Aged
Retinitis Pigmentosa / complications*,  physiopathology
Retreatment
Tomography, Optical Coherence
Treatment Outcome
Visual Acuity / physiology
Visual Fields
Vitreous Body / drug effects
Young Adult
Chemical
Reg. No./Substance:
0/Drug Implants; 0/Glucocorticoids; 7S5I7G3JQL/Dexamethasone
Comments/Corrections
Comment In:
Graefes Arch Clin Exp Ophthalmol. 2013 Dec;251(12):2827-8   [PMID:  23982775 ]
Graefes Arch Clin Exp Ophthalmol. 2013 Dec;251(12):2829   [PMID:  23996148 ]

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