| Intravitreal dexamethasone implant (Ozurdex) for macular edema secondary to retinitis pigmentosa. | |
| | |
MedLine Citation:
|
PMID: 23275039 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: To evaluate the anatomical and functional outcomes of intravitreal dexamethasone implant in patients with macular edema (ME) secondary to retinitis pigmentosa (RP). METHODS: Three patients (four eyes), aged 24 to 46 years, presented with refractory ME secondary to RP. Intravitreal dexamethasone implant (Ozurdex) was administered to treat ME. The anatomical (central macular thickness [CMT]) and functional (best-corrected visual acuity [BCVA]) outcomes as well as adverse events were recorded. RESULTS: All patients completed 6 months follow-up. After intravitreal Ozurdex all patients showed regression of ME. At baseline, mean CMT was 443 ± 185 μm (range 213-619 μm); ME improved to 234 ± 68 μm (range 142-307 μm) at 1 month, to 332 ± 177 μm (range 139-513 μm) at 3 msonth, and to 305 ± 124 μm (range 144-447 μm) at 6 months. Recurrent ME was recorded in 2 patients (both patients at 3 months from intravitreal dexamethasone implant). Retreatment with intravitreal Ozurdex was performed in two patients. Mean BCVA improved form 20/160 (range 20/50-20/200) (baseline) to 20/100 (range 20/40-20/125) at 1 month, to ∼20/125 (range 20/100-20/200) at 3 months, and to ∼ 20/125 (range 20/100-20/160) at 6 months. No serious ocular and systemic adverse events were observed during the study period. CONCLUSIONS: Intravitreal dexamethasone implant provides anatomic and functional improvements and may represent a valuable treatment option for patients with ME secondary to RP. |
| | |
Authors:
|
Mayer Srour; Giuseppe Querques; Nicolas Leveziel; Jennyfer Zerbib; Julien Tilleul; Elise Boulanger-Scemama; Eric H Souied |
Related Documents
:
|
23080429 - Does surgical technique affect the incidence of spondylodiscitis post lumbar micro disc... 23153049 - Comparing the effects of three different intravitreal injection techniques on vitreous ... 8159299 - Idiopathic membranous nephropathy in the elderly. 18704439 - A prospective comparison of laparoscopic and robotic radical nephrectomy for t1-2n0m0 r... 22933499 - The outcome of scapulothoracic fusion for painful winging of the scapula in dystrophic ... 19394509 - Laparoscopic radical versus partial nephrectomy for tumors >4 cm: intermediate-term onc... 19298219 - Economic and clinical evaluation of fondaparinux vs. enoxaparin for thromboprophylaxis ... 11803319 - Repair of critical aortic coarctation in neonatal age. 16774109 - The use of 308-nm excimer laser for dermatoses: experience with 34 patients. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-12-29 |
Journal Detail:
|
Title: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie Volume: - ISSN: 1435-702X ISO Abbreviation: Graefes Arch. Clin. Exp. Ophthalmol. Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-12-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8205248 Medline TA: Graefes Arch Clin Exp Ophthalmol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The molecular genetics of eyelid tumors: recent advances and future directions.
Next Document: A case of thymic Langerhans cell histiocytosis with diabetes insipidus as the first presentation.