| Intravitreal bevacizumab therapy for neovascular age-related macular degeneration with large submacular hemorrhage. | |
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MedLine Citation:
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PMID: 17916314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate functional and anatomic effects of intravitreal bevacizumab (Avastin; Roche Pharma, Vienna, Austria) in patients with neovascular age-related macular degeneration (AMD) with large submacular hemorrhages. DESIGN: Retrospective, clinical study. METHODS: Twenty-one eyes of 19 AMD patients with choroidal neovascularization and large submacular hemorrhage involving the fovea comprising more than 50% of the total lesion area were evaluated. All patients completed at least four months of follow-up; 12 patients fulfilled 12 months or more of follow-up. Patients were treated with up to six intravitreal bevacizumab injections (1 mg/0.04 ml) at a minimum of four-week intervals. Changes from baseline visual acuity (VA) scores, retinal measurements by optical coherence tomography (OCT), angiographic lesion characteristics, and hemorrhage size were analyzed. A safety assessment was performed at all visits. RESULTS: Intravitreal bevacizumab injections were well tolerated in all patients. At month 4, VA was stable or improved (visual loss of 3 acuity lines or fewer) in 100% and improved by at least 3 lines in 9.5%. Comparable results were found at month 12. On average, the central foveal thickness decreased significantly by 55 microm four weeks after the first injection (P < .001) and by 52 microm at month 4 (P = .002). A significant anatomic improvement also was found for maximum retinal thickness, minimum retinal thickness, and foveal volume (P < .05) and was maintained during four months of follow-up. Mean size of hemorrhage was significantly reduced from 19.7 mm(2) at baseline to 2.5 mm(2) at the four-month follow-up (P < .001). CONCLUSIONS: Intravitreal bevacizumab seems to be a promising therapeutic option in eyes with neovascular AMD and large submacular hemorrhages, with a stabilization in VA and anatomic improvement. |
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Authors:
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Eva Stifter; Stephan Michels; Franz Prager; Michael Georgopoulos; Kaija Polak; Cornelia Hirn; Ursula Schmidt-Erfurth |
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Publication Detail:
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Type: Journal Article Date: 2007-10-04 |
Journal Detail:
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Title: American journal of ophthalmology Volume: 144 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-26 Completed Date: 2008-01-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 886-892 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology, Medical University of Vienna, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiogenesis Inhibitors / therapeutic use* Antibodies, Monoclonal / therapeutic use* Choroidal Neovascularization / drug therapy*, etiology Female Follow-Up Studies Humans Injections Macular Degeneration / complications, drug therapy* Male Retina / pathology Retinal Hemorrhage / drug therapy*, etiology Retrospective Studies Tomography, Optical Coherence Vascular Endothelial Growth Factor A / antagonists & inhibitors Visual Acuity / physiology Vitreous Body |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 0/bevacizumab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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