| Intravitreal bevacizumab for retinopathy of prematurity as first line or rescue therapy with focal laser treatment. a case series. | |
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MedLine Citation:
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PMID: 22506618 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objectives. Laser therapy is effective in the treatment of severe forms of retinopathy of prematurity (ROP), and particularly aggressive posterior ROP (APROP), but always damages the retina. We report our preliminary findings in seven premature infants with complicated ROP or APROP who were treated with intravitreal bevacizumab (IVB) as first line monotherapy or rescue therapy combined with laser treatment. Methods. We studied retrospectively seven preterm infants who were affected by APROP (n=4) or pre-threshold ROP (n=3). Infants were treated with IVB (0.625 mg; Avastin®, Roche, Basel, Switzerland) monotherapy (n=2) when they were too sick to undergo lengthy laser treatment. Results. Monotherapy IVB (n=3 eyes) and IVB combined with laser therapy (n=3 eyes) of APROP cases were followed by regression of the ROP and complete peripheral vascularization. The combined therapy with IVB and laser therapy of pre-threshold ROP (5 eyes) produced a regression of neovascularization and good retinal anatomical outcome. Conclusions. In our series IVB was successful in treating ROP in a small cohort of extremely preterm infants with APROP or pre-threshold ROP, both as monotherapy or rescue treatment after laser-therapy, without the development of ocular and systemic short- and long-term adverse effects. |
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Authors:
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Carlo Dani; Saverio Frosini; Pina Fortunato; Giovanna Bertini; Simone Pratesi; Liliana Sollazzi; Roberto Caputo; Agostino La Torre |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-17 |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: - ISSN: 1476-4954 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Surgical and Medical Critical Care, Section of Neonatology, Careggi University Hospital of Florence, Florence, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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