Document Detail

Intravitreal bevacizumab injection in advanced retinopathy of prematurity.
MedLine Citation:
PMID:  22696855     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report the efficacy of intravitreal bevacizumab injection for advanced retinopathy of prematurity (ROP) patients.
MATERIAL AND METHOD: A retrospective chart review was performed for 19 advanced ROP patients (34 eyes), who had intravitreal bevacizumab injection between January 1, 2007 and July 31, 2009 at Chiang Mai University Hospital. The baseline characteristics including gestational age, postmenstrual age of first injection, anterior and posterior segment changes, and complications between treatments to 1-year followed-up were analyzed.
RESULTS: The patients were divided into 2 groups according to the indications for treatment. Group 1, two patients (4 eyes), received initial intravitreal bevacizumab injection followed by laser photocoagulation due to aggressive posterior disease. Group 2, seventeen patients (30 eyes), received intravitreal bevacizumab injection due to persistence of the vascular activity after laser treatment. There were statistical significant difference between the two groups in terms of a mean gestation age, a mean birth weight, and a mean time for first intravitreal injection (p = 0.002, 0.008, and 0.007 respectively). However, there was no statistical significant difference between the two groups in terms of timing for resolution of vascular activity and retinal vasculogenesis across the laser scar (p = 0.172). One patients with aggressive posterior disease progressed to stage 4A ROP with successful anatomical attachment by pars plana vitrectomy. At 1-year follow-up, no other ocular or systemic side effects were observed. There was no statistical significant difference of a mean spherical equivalent between the two groups (p = 0.280).
CONCLUSION: Intravitreal bevacizumab injection is an effective procedure either as an adjuvant or initial treatment in advanced ROP cases.
Janejit Choovuthayakorn; Khiaocham Ubonrat
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  95 Suppl 4     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-06-15     Completed Date:  2012-08-14     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  S70-5     Citation Subset:  IM    
Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
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MeSH Terms
Angiogenesis Inhibitors / administration & dosage*
Antibodies, Monoclonal, Humanized / administration & dosage*
Infant, Newborn
Infant, Premature
Intravitreal Injections
Laser Coagulation*
Retinopathy of Prematurity / therapy*
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal, Humanized; 2S9ZZM9Q9V/bevacizumab

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