Document Detail

Intravitreal bevacizumab (avastin) as an adjuvant for the treatment of posterior scleritis.
MedLine Citation:
PMID:  21860578     Owner:  NLM     Status:  MEDLINE    
We report a case of posterior scleritis effectively managed with intravitreal bevacizumab. A 71-year-old woman was diagnosed with posterior scleritis. Although she was initially treated with systemic steroids, her clinical presentation deteriorated. She was then treated with a single intravitreal injection of bevacizumab and aqueous humor collection. The aqueous level of vascular endothelial growth factor prior to the intravitreal injection was 880.51 pg/mL, greater than that in the healthy control group (p < 0.001). One month later, the scleritis was completely resolved, and the patient remained stable during six months of follow-up. Intravitreal bevacizumab appears to be an effective adjuvant therapy for patients with posterior scleritis.
Ji Won Lim; Joo Hyun Park
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Publication Detail:
Type:  Journal Article     Date:  2011-07-22
Journal Detail:
Title:  Korean journal of ophthalmology : KJO     Volume:  25     ISSN:  1011-8942     ISO Abbreviation:  Korean J Ophthalmol     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-23     Completed Date:  2012-01-17     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  8804513     Medline TA:  Korean J Ophthalmol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  282-4     Citation Subset:  IM    
Department of Ophthalmology, Hallym University Chuncheon Sacred Heart Hospital,#153 Gyo-dong, Chuncheon, Korea.
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MeSH Terms
Angiogenesis Inhibitors / administration & dosage
Antibodies, Monoclonal, Humanized / administration & dosage*
Aqueous Humor / metabolism
Diagnosis, Differential
Fluorescein Angiography
Follow-Up Studies
Fundus Oculi
Interleukin-8 / metabolism
Intravitreal Injections
Microscopy, Acoustic
Scleritis / drug therapy*,  metabolism,  pathology
Vascular Endothelial Growth Factor A / metabolism
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal, Humanized; 0/Interleukin-8; 0/Vascular Endothelial Growth Factor A; 2S9ZZM9Q9V/bevacizumab

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