| Intravitreal bevacizumab for CNV-complicated tilted disk syndrome. | |
| | |
MedLine Citation:
|
PMID: 19412700 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Tilted disc syndrome is a congenital anomaly characterized by an inferonasal "tilting" of the optic disc. We report three patients affected by macular neovascularisation-complicated tilted disk syndrome treated by intravitreal bevacizumab. METHODS: Three interventional case reports are hereby documented. Ophthalmic evaluations were registered, including monthly visual acuity examination, OCT and fluorescein angiography before and after consecutive intravitreal injection of 1.25 mg bevacizumab (0.05 ml, Avastin). RESULTS: All patients, aged more than 65 years, experienced decreased visual acuity after an observation period of 6 (two patients) and 3 months (one patient). Angiographic leakage with neuroretinal rarefaction and RPE/choriocapillary complex elevation at OCT remained persistent in two patients and reduced in one. CONCLUSIONS: No benefit in terms of visual acuity was noted after intravitreal bevacizumab treatments. Larger studies should be conducted to confirm our small series observation. |
| | |
Authors:
|
Paolo Milani; Alfredo Pece; Giuseppe Moretti; Pruneri Lino; Antonio Scialdone |
Publication Detail:
|
Type: Case Reports; Journal Article Date: 2009-05-03 |
Journal Detail:
|
Title: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Volume: 247 ISSN: 1435-702X ISO Abbreviation: Graefes Arch. Clin. Exp. Ophthalmol. Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-08-04 Completed Date: 2009-10-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8205248 Medline TA: Graefes Arch Clin Exp Ophthalmol Country: Germany |
Other Details:
|
Languages: eng Pagination: 1179-82 Citation Subset: IM |
Affiliation:
|
Ospedale Fatebenefratelli-Oftalmico, Corso di Porta Nuova 23, 20100 Milano, Italy. dottpaolomilani@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angiogenesis Inhibitors / therapeutic use* Antibodies, Monoclonal / therapeutic use* Choroidal Neovascularization / drug therapy*, etiology, physiopathology Eye Abnormalities / complications* Female Fluorescein Angiography Humans Injections Male Optic Disk / abnormalities* Syndrome Tomography, Optical Coherence Treatment Outcome Vascular Endothelial Growth Factor A / antagonists & inhibitors Visual Acuity / physiology Vitreous Body |
| Chemical | |
Reg. No./Substance:
|
0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal; 0/Vascular Endothelial Growth Factor A; 0/bevacizumab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prevalence, characteristics and a neurocognitive model of mirror-touch synaesthesia.
Next Document: Dose-related changes in retinal function and PKC-alpha expression in rabbits on vigabatrin medicatio...