Document Detail


Intravesical CDDP therapy compared with combined CDDP and external radiation in noninvasive bladder cancer. Monitored with quantitative fluorescence cytology.
MedLine Citation:
PMID:  6539999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Results of intravesical CDDP or CDDP combined with external beam radiation are compared in a group of 13 patients with low-stage bladder cancer. Six patients with low-stage bladder cancer received 4 or 12 treatments of CDDP intravesically with an initial complete response in 3 patients. Within six months, recurrent disease developed in 2 of 3 patients. Seven patients received the combination therapy of 400 rad (weekly for six weeks) followed two hours later with 50 mg of intravesical CDDP. A positive response was observed initially in all 7 patients as determined by pathology, PAP cytology, fluorescence cytology, and quantitative nuclear fluorescence determinations. Therapy was discontinued in 1 patient in each group because of irritative symptoms. The results indicate combination therapy is of tolerable toxicity, and quantitative fluorescence cytology is a useful adjuvant for guiding future treatments in patients with low- and high-grade bladder tumors.
Authors:
G P Hemstreet; S S West; W L Weems; S McFarland; C K Echols
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Urology     Volume:  24     ISSN:  0090-4295     ISO Abbreviation:  Urology     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-08-03     Completed Date:  1984-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  59-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Carcinoma / drug therapy,  pathology,  radiotherapy,  therapy*
Cisplatin / therapeutic use*
Combined Modality Therapy
Female
Humans
Male
Microscopy, Fluorescence
Middle Aged
Neoplasm Recurrence, Local / pathology,  therapy
Urinary Bladder Neoplasms / drug therapy,  pathology,  radiotherapy,  therapy*
Chemical
Reg. No./Substance:
15663-27-1/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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