Document Detail

Intraventricular nerve growth factor infusion: a possible treatment for neurological deficits following hypoxic-ischemic brain injury in infants.
MedLine Citation:
PMID:  16197811     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE AND IMPORTANCE: Hypoxic-ischemic brain injuries in childhood are associated with poor neurological outcome. Unfortunately, no new therapeutic approaches have been proposed. Recently, animal studies show that nerve growth factor (NGF) can reduce neurological deficits following hypoxic-ischemic brain injuries. The objective of this study is to demonstrate the therapeutic effects of intraventricular NGF infusion in severe post-ischemic damage. CLINICAL PRESENTATION: Two infants, aged 9 and 8 months, with hypoxic-ischemic brain damage, secondary to prolonged cardiorespiratory arrest and stabilized after the conventional treatment, were treated with intraventricular NGF infusion. Before the therapy both infants were comatose with asymmetrical tetraparesis; their Glasgow Coma Scale (GCS) was 4 and 5, respectively. One month after the treatment, their GCS was 8 and 9, respectively. EEG examinations performed after the NGF infusion showed an increased alpha/theta ratio. MRI showed a reduction of malacic areas in the brain. A SPECT study, performed only in one infant, demonstrated that the NGF treatment resulted in an improvement of regional cerebral perfusion in right temporal and occipital cortices. INTERVENTION: The drug utilized was 2.5S NGF purified and lyophilized from male mouse submaxillary glands. NGF infusion was started about 30 days after the hypoxic-ischemic brain injury. 0.1 mg NGF was administered via the external drainage catheter into the right cerebral ventricle once a day for 10 days consecutively. CONCLUSION: Our observations are interesting, but further studies are necessary to confirm the effects of NGF in hypoxic-ischemic brain injuries in infants.
Antonio Chiaretti; Orazio Genovese; Riccardo Riccardi; Concezio Di Rocco; Daniela Di Giuda; Paolo Mariotti; Silvia Pulitanò; Marco Piastra; Giancarlo Polidori; Giovanna Stefania Colafati; Luigi Aloe
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurological research     Volume:  27     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-03     Completed Date:  2005-11-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  741-6     Citation Subset:  IM    
Pediatric Intensive Care Unit, Catholic University Medical School, Rome, Italy.
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MeSH Terms
Cerebral Ventricles
Hypoxia-Ischemia, Brain / diagnosis,  drug therapy*,  physiopathology,  radionuclide imaging
Infusions, Parenteral
Magnetic Resonance Imaging
Nerve Growth Factor / administration & dosage*,  therapeutic use*
Tomography, Emission-Computed, Single-Photon
Treatment Outcome
Reg. No./Substance:
9061-61-4/Nerve Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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