Document Detail

Intraventricular melanin-concentrating hormone stimulates water intake independent of food intake.
MedLine Citation:
PMID:  12557891     Owner:  NLM     Status:  MEDLINE    
The lateral hypothalamus (LH) has a critical role in the control of feeding and drinking. Melanin-concentrating hormone (MCH) is an orexigenic peptidergic neurotransmitter produced primarily in the LH, and agouti-related protein (AgRP) is an orexigenic peptidergic neurotransmitter produced exclusively in the arcuate (ARC), an area that innervates the LH. We assessed drinking and eating after third ventricular (i3vt) administration of MCH and AgRP. MCH (2.5, 5, and 10 micro g i3vt) significantly increased food as well as water intake over 4 h when administered during either the light or the dark portion of the day-night cycle. When MCH (5 micro g) was administered to rats with access to water but no food, they drank significantly more water than when given the vehicle. AgRP (7 micro g i3vt), on the other hand, increased water intake but only in proportion to food intake during the dark and the light, and water intake was not increased after i3vt AgRP in the absence of food. Hence, in contrast to AgRP, MCH elicits increased water intake independent of food intake. These results are consistent with historical data linking activity of the LH with water as well as food intake.
Deborah J Clegg; Ellen L Air; Stephen C Benoit; Randall S Sakai; Randy J Seeley; Stephen C Woods
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  284     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-30     Completed Date:  2003-02-21     Revised Date:  2011-08-03    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R494-9     Citation Subset:  IM    
Department of Psychiatry, University of Cincinnati, Ohio 45267, USA.
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MeSH Terms
Agouti-Related Protein
Circadian Rhythm
Diuresis / drug effects
Drinking Behavior / drug effects*
Feeding Behavior / drug effects*
Hypothalamic Hormones / administration & dosage*,  pharmacology*
Injections, Intraventricular
Intercellular Signaling Peptides and Proteins
Melanins / administration & dosage*,  pharmacology*
Osmolar Concentration
Pituitary Hormones / administration & dosage*,  pharmacology*
Proteins / administration & dosage,  pharmacology
Rats, Long-Evans
Grant Support
Reg. No./Substance:
0/AGRP protein, rat; 0/Agouti-Related Protein; 0/Hypothalamic Hormones; 0/Intercellular Signaling Peptides and Proteins; 0/Melanins; 0/Pituitary Hormones; 0/Proteins; 67382-96-1/melanin-concentrating hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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