| Intraventricular melanin-concentrating hormone stimulates water intake independent of food intake. | |
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MedLine Citation:
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PMID: 12557891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The lateral hypothalamus (LH) has a critical role in the control of feeding and drinking. Melanin-concentrating hormone (MCH) is an orexigenic peptidergic neurotransmitter produced primarily in the LH, and agouti-related protein (AgRP) is an orexigenic peptidergic neurotransmitter produced exclusively in the arcuate (ARC), an area that innervates the LH. We assessed drinking and eating after third ventricular (i3vt) administration of MCH and AgRP. MCH (2.5, 5, and 10 micro g i3vt) significantly increased food as well as water intake over 4 h when administered during either the light or the dark portion of the day-night cycle. When MCH (5 micro g) was administered to rats with access to water but no food, they drank significantly more water than when given the vehicle. AgRP (7 micro g i3vt), on the other hand, increased water intake but only in proportion to food intake during the dark and the light, and water intake was not increased after i3vt AgRP in the absence of food. Hence, in contrast to AgRP, MCH elicits increased water intake independent of food intake. These results are consistent with historical data linking activity of the LH with water as well as food intake. |
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Authors:
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Deborah J Clegg; Ellen L Air; Stephen C Benoit; Randall S Sakai; Randy J Seeley; Stephen C Woods |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 284 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-01-30 Completed Date: 2003-02-21 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R494-9 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Cincinnati, Ohio 45267, USA. debbie.clegg@uc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Agouti-Related Protein Animals Circadian Rhythm Diuresis / drug effects Drinking Behavior / drug effects* Feeding Behavior / drug effects* Hypothalamic Hormones / administration & dosage*, pharmacology* Injections, Intraventricular Intercellular Signaling Peptides and Proteins Male Melanins / administration & dosage*, pharmacology* Osmolar Concentration Pituitary Hormones / administration & dosage*, pharmacology* Proteins / administration & dosage, pharmacology Rats Rats, Long-Evans |
| Grant Support | |
ID/Acronym/Agency:
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DK-17844/DK/NIDDK NIH HHS; DK-48061/DK/NIDDK NIH HHS; DK-54890/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/AGRP protein, rat; 0/Agouti-Related Protein; 0/Hypothalamic Hormones; 0/Intercellular Signaling Peptides and Proteins; 0/Melanins; 0/Pituitary Hormones; 0/Proteins; 67382-96-1/melanin-concentrating hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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