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Intraventricular inflammatory pseudotumor: Report of two cases and review of the literature.
MedLine Citation:
PMID:  21133999     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Inflammatory pseudotumors (IP) are non-neoplastic lesions characterized by collagenous stroma and polyclonal mononuclear infiltrates. It is best characterized in the lung, but can occur in the CNS, mimicking a neoplastic process. We discuss the available literature and our cases in order to elucidate best medical practices when confronted with such a lesion. We report on two cases of intraventricular inflammatory pseudotumor in patients who presented with symptoms of CSF obstruction. Both patients were treated surgically with significant clinical improvement. Histopathologically, both specimens revealed a plasma cell granuloma variant of IP. A Medline search for English articles identified 46 cases of CNS IP, only eight of which were located within the ventricle. As with our case, most patients presented due to CSF obstruction or mass effect. Radiographically, the lesions have a variable appearance although most enhanced with gadolinium. Complete resection was achieved in 67% with a 12% rate of recurrence. With incomplete resection or biopsy alone, progression is seen despite steroid or radiation administration. Malignant transformation was only reported once. CNS IP is a rare pathological entity that cannot be diagnosed through clinical presentation or radiographic characteristics, but rather through a careful neuropathological inspection. The available literature suggests that complete resection with close follow-up is necessary.
Authors:
Ravi H Gandhi; Li Li; Jiang Qian; Yu Hung Kuo
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Publication Detail:
Type:  Journal Article     Date:  2010-12-06
Journal Detail:
Title:  Neuropathology : official journal of the Japanese Society of Neuropathology     Volume:  31     ISSN:  1440-1789     ISO Abbreviation:  Neuropathology     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606526     Medline TA:  Neuropathology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  446-54     Citation Subset:  IM    
Copyright Information:
© 2010 Japanese Society of Neuropathology.
Affiliation:
Division of Neurosurgery, The Neurosciences Institute Department of Pathology, Albany Medical Center, Albany, New York, USA.
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