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Intraventricular hemorrhage in preterm infants: coagulation perspectives.
MedLine Citation:
PMID:  22187395     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
It has long been considered that a severe coagulation deficiency in premature newborns could be a major contributing factor in the occurrence of intraventricular hemorrhage (IVH). High-grade IVH has also been shown to coincide with severe derangement of coagulation in extremely low birth weight infants. This review focuses on the relevance of the physiologically developing immature hemostatic system to IVH, and the potential benefit of agents affecting hemostasis for IVH therapy or prevention in preterm infants. The findings of small, open-label interventional studies on the effect of ethamsylate, vitamin K, fresh frozen plasma, recombinant activated factor VII, and prothrombin complex concentrate on the premature coagulation system will be reviewed.
Authors:
Amir A Kuperman; Gili Kenet; Emmanuel Papadakis; Benjamin Brenner
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Publication Detail:
Type:  Journal Article     Date:  2011-12-20
Journal Detail:
Title:  Seminars in thrombosis and hemostasis     Volume:  37     ISSN:  1098-9064     ISO Abbreviation:  Semin. Thromb. Hemost.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0431155     Medline TA:  Semin Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  730-6     Citation Subset:  IM    
Copyright Information:
© Thieme Medical Publishers.
Affiliation:
Pediatric Hematology Clinic, Thrombosis and Hemostasis Service, Institute of Hematology, Western Galilee Hospital, Naharriya, Israel.
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