Document Detail


Intraventricular hemorrhage and developmental outcomes at 24 months of age in extremely preterm infants.
MedLine Citation:
PMID:  22232137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Whether intraventricular hemorrhage increases the risk of adverse developmental outcome among premature infants is controversial. Using brain ultrasound, we identified intraventricular hemorrhage and white matter abnormalities among 1064 infants born before 28 weeks' gestation. We identified adverse developmental outcomes at 24 months of age using a standardized neurologic examination and the Bayley Scales of Infant Development Mental and Motor Scales. In logistic regression models that adjusted for gestational age, sex, and public insurance, isolated intraventricular hemorrhage was associated with visual fixation difficulty but no other adverse outcome. Infants who had a white matter lesion unaccompanied by intraventricular hemorrhage were at increased risk of cerebral palsy, low Mental and Motor Scores, and visual and hearing impairments. Except when accompanied or followed by a white matter lesion, intraventricular hemorrhage is associated with no more than a modest increase (and possibly no increase) in the risk of adverse developmental outcome during infancy.
Authors:
T Michael O'Shea; Elizabeth N Allred; Karl C K Kuban; Deborah Hirtz; Barbara Specter; Sara Durfee; Nigel Paneth; Alan Leviton;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of child neurology     Volume:  27     ISSN:  1708-8283     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-10     Completed Date:  2012-05-15     Revised Date:  2013-07-31    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  22-9     Citation Subset:  IM    
Affiliation:
Wake Forest School of Medicine, Winston-Salem, NC, USA.
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MeSH Terms
Descriptor/Qualifier:
Cerebral Hemorrhage / etiology*
Cerebral Palsy / etiology,  ultrasonography
Child, Preschool
Developmental Disabilities / etiology*
Female
Gestational Age
Head / pathology
Humans
Infant, Newborn
Infant, Premature, Diseases / etiology*
Logistic Models
Male
Multivariate Analysis
Neurologic Examination
Premature Birth / physiopathology*
Ultrasonography, Doppler
Vision Disorders / etiology
Grant Support
ID/Acronym/Agency:
5P30HD018655-28/HD/NICHD NIH HHS; 5U01NS040069-05/NS/NINDS NIH HHS; P30 HD018655/HD/NICHD NIH HHS; U01 NS040069/NS/NINDS NIH HHS
Investigator
Investigator/Affiliation:
Kristen Ecklund / ; Haim Bassan / ; Samantha Butler / ; Adré Duplessis / ; Cecil Hahn / ; Catherine Limperopoulos / ; Omar Khwaja / ; Janet S Soul / ; Bhavesh Shah / ; Frederick Hampf / ; Herbert Gilmore / ; Susan McQuiston / ; Camilia R Martin / ; Jane Share / ; Linda J Van Marter / ; Sara Durfee / ; Robert M Insoft / ; Cynthia Cole / ; John M Fiascone / ; Roy McCauley / ; Paige T Church / ; Cecelia Keller / ; Karen J Miller / ; Francis Bednarek / ; Jacqueline Wellman / ; Robin Adair / ; Richard Bream / ; Alice Miller / ; Albert Scheiner / ; Christy Stine / ; Richard Ehrenkranz / ; Cindy Miller / ; Nancy Close / ; Elaine Romano / ; Joanne Williams / ; Barbara Specter / ; Deborah Allred / ; Robert Dillard / ; Don Goldstein / ; Deborah Hiatt / ; Gail Hounshell / ; Ellen Waldrep / ; Lisa Washburn / ; Cherrie D Welch / ; Stephen C Engelke / ; Ira Adler / ; Sharon Buckwald / ; Rebecca Helms / ; Kathyrn Kerkering / ; Scott S MacGilvray / ; Peter Resnik / ; Carl Bose / ; Lynn A Fordham / ; Lisa Bostic / ; Diane Marshall / ; Kristi Milowic / ; Janice Wereszczak / ; Mariel Poortenga / ; Bradford W Betz / ; Steven L Bezinque / ; Joseph Junewick / ; Wendy Burdo-Hartman / ; Lynn Fagerman / ; Kim Lohr / ; Steve Pastyrnak / ; Dinah Sutton / ; Ellen Cavenagh / ; Victoria J Caine / ; Nicholas Olomu / ; Joan Price / ; Nigel Paneth / ; Padmani Karna / ; Michael D Schreiber / ; Kate Feinstein / ; Leslie Caldarelli / ; Sunila E O'Connor / ; Michael Msall / ; Susan Plesha-Troyke / ; Daniel Batton / ; Karen Brooklier / ; Beth Kring / ; Melisa J Oca / ; Katherine M Solomon / ; Joanna J Seibert / ; Robert Lorenzo / ; Camilia R Martin / ; Linda J Van Marter / ; Sara Durfee / ; Alan Leviton / ; Kirsten Ecklund / ; Robert Insoft / ; Cynthia Cole / ; John Fiascone / ; Roy McCauley / ; Francis Bednarek / ; Jacqueline Wellman / ; Richard Ehrenkranz / ; Cindy Miller / ; T Michael O'Shea / ; Barbara Specter / ; Stephen Engelke / ; Ira Adler / ; Carl Bose / ; Lynn Fordham / ; Mariel Portenga / ; Bradford W Betz / ; Steven Bezinque / ; Joseph Junewick / ; Karna Padmani / ; Ellen Cavenagh / ; Nigel Paneth / ; Michael D Schreiber / ; Kate Feinstein / ; Daniel Batton / ; Robert Lorenzo / ; Joanna Sieber / ; Jane Share /
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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