Document Detail

Intravenous versus intracoronary streptokinase in acute myocardial infarction.
MedLine Citation:
PMID:  4075606     Owner:  NLM     Status:  MEDLINE    
Nine studies specifically dealing with the comparison of intravenous streptokinase (IVSK) and intracoronary streptokinase (ICSK) in the treatment of acute myocardial infarction (MI) were analyzed to determine if IVSK is as efficacious as ICSK in achieving thrombolysis. Pooled data from the studies yielded success rates of 73% for IVSK and 72% for ICSK. Considering that the studies which did not perform preintervention angiogram may have overestimated the thrombolytic success rate in IVSK patients, there is a possibility that ICSK may be slightly more effective in achieving acute reperfusion. Bleeding complications were similar, and a systemic lytic state was observed in both treatment groups. No definitive conclusions can be drawn regarding the differences between groups in improvements of left ventricular function and mortality rates. ICSK has the advantage of direct documentation of reperfusion and spares the patient the risk of anticoagulation should the attempt fail. On the other hand, IVSK is cheaper, easier to administer, and can logistically be given earlier (even in the emergency room or ambulance) than ICSK; it is therefore more widely available, and may be the preferred mode of treatment in community hospitals where cardiac catheterization facilities are not readily available, if streptokinase is to be given at all.
Y S Lo
Related Documents :
1896206 - The effect of streptokinase on chest pain in acute myocardial infarction.
3690906 - Nifedipine infusion in acute myocardial infarction: experience in twelve patients.
3127076 - Combined use of nitroglycerin and n-acetylcysteine in the management of unstable angina...
1854566 - Thrombolytic treatment in acute myocardial infarction: neutrophil activation, periphera...
2601006 - Role of pmn elastase on ischemic myocardial injury in evolving myocardial infarction: c...
10187896 - Antiplatelet therapy in acute cerebral ischemia.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  8     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-01-31     Completed Date:  1986-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  609-19     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiac Output / drug effects
Coronary Circulation / drug effects
Coronary Vessels / drug effects*
Dose-Response Relationship, Drug
Infusions, Parenteral
Myocardial Contraction / drug effects
Myocardial Infarction / drug therapy*,  mortality
Streptokinase / administration & dosage*,  adverse effects
Reg. No./Substance:
EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Blood volume changes in normal pregnancy.
Next Document:  The significance of repeated exercise testing with thallium-201 scanning in asymptomatic diabetic ma...