| Intravenous valproate aborts glyceryl trinitrate-induced migraine attacks: a clinical and quantitative EEG study. | |
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MedLine Citation:
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PMID: 18201252 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated EEG changes and pain relief in migraineurs with glyceryl trinitrate (GTN)-induced attacks treated with intravenous sodium valproate (iSVP). EEG frequency analysis was performed in 45 migraineurs without aura and in 19 controls at baseline, at the time of maximum GTN-induced headache, and 30 min after 300 mg iSVP. Nineteen migraineurs presented early specific headache (migraine identical to spontaneous attacks; MSp) and 26 presented early non-specific headache (MnSp). During attacks in MSp there was an increase of theta [16.6% (14.8-19.3) to 19.4% (17.4-22.1), P = 0.02] and delta activity [3.6% (3.1-4.4) to 5.4% (3.9-6.5), P = 0.009], whereas there was no decrease in alpha [41.4% (36.2-45.1) to 39.7% (34.7-44.8)] or beta activity [37.6% (34.7-40.3) to 35.1% (33.5-38.8)]. iSVP reduced migraine from severe/moderate to mild/no pain in 17 (90%) MSp patients, and was associated with reversion of the slow rhythmic activity to baseline levels [theta 16.9% (14.6-18.9); delta 3.2% (3-4.1)]. There was no change in EEG frequency activity after administration of GTN or iSVP in controls and in MnSp. iSVP is well tolerated and effective in treating GTN-induced migraine in migraineurs without aura, and appears to restore the disturbances of cortical electrogenesis associated with these attacks. |
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Authors:
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T Thomaides; T Karapanayiotides; E Kerezoudi; T Avramidis; C Haeropoulos; Y Zoukos; A Spantideas |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-01-15 |
Journal Detail:
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Title: Cephalalgia : an international journal of headache Volume: 28 ISSN: 1468-2982 ISO Abbreviation: Cephalalgia Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-07 Completed Date: 2008-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200710 Medline TA: Cephalalgia Country: England |
Other Details:
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Languages: eng Pagination: 250-6 Citation Subset: IM |
Affiliation:
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Department of Neurology, Greek Red Cross Hospital, Athens, Greece. thomaides@ath.forthnet.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Electroencephalography / drug effects*, methods Female Humans Infusions, Intravenous Male Migraine without Aura / chemically induced, drug therapy*, physiopathology* Nitroglycerin / toxicity* Valproic Acid / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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55-63-0/Nitroglycerin; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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