| Intravenous pulse cyclophosphamide--is it effective in children with steroid-resistant nephrotic syndrome? | |
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MedLine Citation:
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PMID: 13680329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment of steroid-resistant nephrotic syndrome (SRNS) remains a challenge to pediatric nephrologists. Recently, intravenous cyclophosphamide (IV-CPM) infusion was shown to be effective, safe, and economical for the treatment of SRNS, particularly minimal change disease (MCD), as it results in more sustained remissions, longer periods without proteinuria, and fewer significant side effects at a lower cumulative dose. A prospective study was conducted to evaluate IV-CPM infusions in the management of children with SRNS secondary to MCD or IgM nephropathy. Five patients with SRNS (4 IgM nephropathy and 1 MCD) received six monthly IV-CPM infusions at a dose of 500 mg/m(2). No patient achieved complete or sustained remission. Three patients attained partial remission, which was not sustained for more than 1 month post therapy. One patient progressed rapidly to end-stage renal disease during treatment. Side effects included vomiting in four patients and alopecia in one patient. Conclusion: IV-CPM pulse therapy at a dose of 500 mg/m(2) is unsuccessful in obtaining complete or sustained remission in children with SRNS secondary to IGM nephropathy or MCD. Further randomized controlled studies with higher doses are required. |
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Authors:
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Hammad O Alshaya; Jaudah A Al-Maghrabi; Jameela A Kari |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2003-09-17 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 18 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-10-30 Completed Date: 2004-06-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 1143-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, King Abdul Aziz University Hospital, PO Box 80215, Jeddah 21589, Saudi Arabia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child, Preschool Cyclophosphamide / administration & dosage*, adverse effects Drug Resistance Female Glomerulonephritis, IGA / complications Humans Immunosuppressive Agents / administration & dosage*, adverse effects Infant Injections, Intravenous Male Nephrosis, Lipoid / complications Nephrotic Syndrome / drug therapy*, etiology Pulse Therapy, Drug Steroids / therapeutic use Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 0/Steroids; 50-18-0/Cyclophosphamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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