| Intravenous pinacidil in the acute treatment of hypertension. | |
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MedLine Citation:
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PMID: 3308975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pinacidil (N''-cyano-N-4-pyridyls-N'-1,2,2-trimethyl-propyl guanidine, monohydrate), a recently developed direct-acting vasodilator, was given intravenously in a dosage of 0.1-0.2 mg/kg body weight to ten untreated hypertensive patients. Pinacidil caused a fall of blood pressure from 170/108 +/- 6/3 to 156/80 +/- 5/4 mm Hg (mean +/- SE). The proportional decrease of mean arterial pressure (MAP) was 13.7 +/- 1.6%. Together with the decrease of blood pressure an increase of heart rate by 29.7 +/- 6.2% occurred. The heart rate increased by 13.6 beats/min per 10 mm Hg decrease of MAP. Pinacidil also caused significant rise of plasma noradrenaline and plasma renin activity, whereas plasma adrenaline and aldosterone remained unchanged. The serum concentrations of pinacidil and its major metabolite pinacidil-N-oxide were within the expected limits. The authors conclude that intravenously administered pinacidil causes a rapid decrease of blood pressure, but at the cost of a considerable increase of heart rate, and thus does not offer advantages over other vasodilators. |
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Authors:
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M C Rijk; T Thien |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: 27 ISSN: 0091-2700 ISO Abbreviation: J Clin Pharmacol Publication Date: 1987 Jul |
Date Detail:
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Created Date: 1987-11-10 Completed Date: 1987-11-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 468-74 Citation Subset: IM |
Affiliation:
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Department of Medicine, University Hospital, Nijmegen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antihypertensive Agents / administration & dosage, therapeutic use* Blood Pressure / drug effects Epinephrine / blood Female Guanidines / administration & dosage, therapeutic use* Heart Rate / drug effects Humans Hypertension / drug therapy* Injections, Intravenous Male Middle Aged Norepinephrine / blood Pinacidil Renin / blood Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Guanidines; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 85371-64-8/Pinacidil; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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