| Intravenous phosphate in the intensive care unit: more aggressive repletion regimens for moderate and severe hypophosphatemia. | |
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MedLine Citation:
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PMID: 12845429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate efficacy and safety of aggressive correction of hypophosphatemia with intravenous potassium phosphate in the ICU. DESIGN AND SETTING: Randomized interventional prospective study in the medical and surgical ICU of a tertiary university hospital. PATIENTS: Critically ill patients with hypophosphatemia between June and November 1998. MEASUREMENTS AND RESULTS: Patients with moderate hypophosphatemia (<0.65 and >0.40 mmol/l; n=37) were randomized into two groups: group 1 received 30 mmol potassium phosphate intravenously in 50 ml saline over 2 h, and group 2 received 30 mmol potassium phosphate in 100 ml saline over 4 h. Patients with severe hypophosphatemia (<0.40 mmol/l; n=10) were also randomized into two groups: group 3 received 45 mmol potassium phosphate intravenously in 100 ml saline over 3 h, and group 4 received 45 mmol potassium phosphate in 100 ml saline over 6 h. Electrolytes, blood gas, renal function were monitored until day 3; urine was collected during and until 6 h after infusions. The overall efficacy of the protocols was 98% by the end of the infusion. There was no statistical difference in phosphate values between groups at the end of infusion or at 24 h. No adverse events were noted; one patient had an increase in serum potassium to 6.1 mmol/l. Phosphaturia in all groups was elevated as evidenced by fractional excretion above 20%. CONCLUSIONS: More rapid administration of large potassium phosphate boluses is effective and safe for correcting hypophosphatemia in ICU patients with preserved renal function if baseline serum potassium is below 4 mmol/l. |
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Authors:
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Thierry Charron; Francis Bernard; Yoanna Skrobik; Nathalie Simoneau; Nadine Gagnon; Martine Leblanc |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial Date: 2003-07-05 |
Journal Detail:
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Title: Intensive care medicine Volume: 29 ISSN: 0342-4642 ISO Abbreviation: Intensive Care Med Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-07 Completed Date: 2005-04-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 1273-8 Citation Subset: IM |
Affiliation:
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Medical and Surgical Intensive Care Units, Maisonneuve-Rosemont Hospital, University of Montreal, 5415 de l'Assomption, H1T 2M4, Montreal, PQ, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Female Humans Hypophosphatemia / drug therapy*, physiopathology Infusion Pumps Intensive Care Units Male Middle Aged Phosphates / administration & dosage, therapeutic use* Potassium Compounds / administration & dosage, therapeutic use* Prospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Phosphates; 0/Potassium Compounds; 16068-46-5/potassium phosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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