Document Detail

Intravenous pentazocine and methylphenidate abuse during pregnancy. Maternal lifestyle and infant outcome.
MedLine Citation:
PMID:  7692723     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report the effects of intravenous abuse of pentazocine hydrochloride and methylphenidate hydrochloride during pregnancy. DESIGN: Retrospective chart review. PATIENTS: All pregnant women and their offspring, whose hospital records indicated prenatal abuse of pentazocine and methylphenidate during the 2-year study period. RESULTS: The median for maternal age was 22 years and the median number of prenatal visits was two. Twenty mothers had sexually transmitted diseases, 27 abused alcohol, 10 abused other drugs, and all smoked cigarettes. Eight infants were premature, and 12 were growth retarded. Four infants had congenital anomalies: fetal alcohol syndrome (two [twins]), structural heart defect (one), and polydactyly (one). Eleven infants were treated for neonatal abstinence syndrome. Seventeen infants had normal developmental quotients, and four had low-normal developmental quotients. CONCLUSIONS: Intrauterine exposure to pentazocine and methylphenidate appears to be associated with prematurity, growth retardation, and signs of neonatal withdrawal, but not with any particular teratogenic anomaly or severe developmental delay.
V D Debooy; M M Seshia; M Tenenbein; O G Casiro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  147     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-11-04     Completed Date:  1993-11-04     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1062-5     Citation Subset:  AIM; IM    
Newborn Follow-Up Program, Health Sciences Centre, Winnipeg, Manitoba, Canada.
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MeSH Terms
Developmental Disabilities / etiology
Fetal Growth Retardation / etiology
Follow-Up Studies
Health Behavior
Infant, Newborn
Infant, Premature
Maternal Behavior
Neonatal Abstinence Syndrome / etiology
Pregnancy Complications*
Pregnancy Outcome*
Substance Abuse, Intravenous* / psychology
Reg. No./Substance:
113-45-1/Methylphenidate; 359-83-1/Pentazocine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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