Document Detail

Intravenous penicillin desensitization and treatment during pregnancy.
MedLine Citation:
PMID:  3773158     Owner:  NLM     Status:  MEDLINE    
Untreated syphilis during pregnancy may result in stillbirth in one fourth of cases, while in infants who survive, there may be serious immediate and delayed manifestations. Penicillin is the drug of choice for treating both mother and fetus. We describe a woman with an allergy against both major and minor determinants of penicillin in whom syphilis was diagnosed on routine obstetric screening. Her obstetric history included one vaginal delivery at term and four subsequent spontaneous abortions at 12 to 16 weeks. The patient underwent desensitization utilizing graduated intravenous doses of penicillin followed by treatment with a constant infusion for eight days. She experienced no serious allergic reactions requiring alteration of therapy. We conclude that antibiotic desensitization may be a safe alternative during pregnancy if performed with careful monitoring. In this case, it allowed use of penicillin rather than less desirable alternatives.
P R Ziaya; G D Hankins; L C Gilstrap; A B Halsey
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  JAMA     Volume:  256     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-11-28     Completed Date:  1986-11-28     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2561-2     Citation Subset:  AIM; IM    
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MeSH Terms
Desensitization, Immunologic / methods*
Drug Hypersensitivity / therapy*
Penicillin G / immunology,  therapeutic use*
Pregnancy Complications, Infectious / drug therapy*
Syphilis / drug therapy*
Reg. No./Substance:
Q42T66VG0C/Penicillin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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