| Intravenous and oral administration of amiodarone for the treatment of recent onset atrial fibrillation after digoxin administration. | |
| | |
MedLine Citation:
|
PMID: 17434635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Atrial fibrillation (AF) remains a significant contributor to cardiovascular morbidity. Amiodarone is a potent antiarrhythmic drug. The safety and efficacy of oral versus intravenous (i.v.) Amiodarone in the treatment of AF of recent onset (duration <48 h) was investigated. METHODS: The study population consisted of 223 patients with symptomatic AF, of whom 110 received 600 mg oral Amiodarone (Group A) in three divided doses and 113 received i.v. Amiodarone (5 mg/kg over 30 min followed by 1000 mg over the next 24 h) (Group B). Digoxin was administered to all patients, who had not previously received it. All patients were monitored for 24 h. RESULTS: Conversion to sinus rhythm occurred in 85.45% of group A and 82.30% in group B (p=NS). Mean time of cardioversion in group A was 20+/-4.5 h and in group B was 12+/-8 h (p<0,001). However, blood pressure (BP) in group A remained stable for the observation period, whereas it fell significantly in group B. Treatment was not discontinued in any of the patients in either group, however 13 patients in group B developed superficial phlebitis. CONCLUSIONS: Both forms of the drug are extremely efficient in restoring sinus rhythm in AF of recent onset, although the i.v. form acts quicker. The oral form of the drug does not alter significantly the patients' BP. |
| | |
Authors:
|
Theodoros Xanthos; Eleni Bassiakou; Ioannis S Vlachos; Sotirios Bassiakos; Konstantinos Michalakis; Dimitris-Anestis Moutzouris; Lila Papadimitriou |
Related Documents
:
|
2463565 - Is ddd superior to vvi pacing in mixed carotid sinus syndrome? an acute and medium-term... 6376595 - Cibenzoline for treatment of ventricular arrhythmias: a double-blind placebo-controlled... 17670055 - Measurement of troponin t and i to detect cardioprotective effect of aminophylline duri... 6846115 - Reduction of ventricular ectopic beats with oral acebutolol: a double-blind, randomized... 15834035 - Evaluating neurorehabilitation: lessons from routine data collection. 10420495 - Efficacy of fluoxetine in austrian patients with obsessive-compulsive disorder. |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial Date: 2007-04-16 |
Journal Detail:
|
Title: International journal of cardiology Volume: 121 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2007 Oct |
Date Detail:
|
Created Date: 2007-10-01 Completed Date: 2007-11-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 291-5 Citation Subset: IM |
Affiliation:
|
University of Athens Medical School Department of Experimental Surgery and Surgical Research, Greece. theodorosxanthos@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Aged Amiodarone / administration & dosage* Anti-Arrhythmia Agents / administration & dosage* Atrial Fibrillation / drug therapy* Blood Pressure / drug effects Digoxin / administration & dosage Electrocardiography Female Humans Infusions, Intravenous Male Middle Aged Statistics, Nonparametric Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone; 20830-75-5/Digoxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association between serum resistin and carotid intima media thickness in hypertension patients.
Next Document: Interactions between the chemical senses: trigeminal function in patients with olfactory loss.