Document Detail

Intravenous nutrient-induced satiety depends on feeding-related gut signals.
MedLine Citation:
PMID:  1877689     Owner:  NLM     Status:  MEDLINE    
To determine whether feeding-generated gut signals act in conjunction with intravenous nutrients to suppress food intake, nutrients were infused intravenously to dark-fed rats during different portions of the 12:12 h light-dark cycle. During 4-day test periods rats received 35.5-37 kcal/day of a solution containing 25% glucose-4.25% amino acids. Food intakes were reduced by 40.5 +/- 1.1 and 30.7 +/- 1.8 kcal or 110 and 87% of the calories infused in the dark (fed) phase over 8 and 12 h, respectively. When administered in the light phase while rats were fasted, 8- and 12-h infusions reduced food intake significantly less than in the dark: 21.3 +/- 1.1 and 19.6 +/- 0.7 kcal/day or only 57 and 55% of the infused calories, respectively. With 24-h infusions, as in previous studies, food intake was reduced by 24.5 +/- 2.1 kcal/day or 68% of the infused calories. These results suggest that gut signals generated by concurrent feeding act with intravenous glucose and amino acids to produce a more compensatory reduction in daily food intake.
E K Walls; A E Willing; H S Koopmans
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  261     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-09-23     Completed Date:  1991-09-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R313-22     Citation Subset:  IM    
Department of Medical Physiology, University of Calgary, Alberta, Canada.
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MeSH Terms
Animal Nutritional Physiological Phenomena*
Infusions, Intravenous
Intestines / physiology*
Rats, Inbred Lew
Satiety Response / physiology*
Sodium Chloride / pharmacology
Time Factors
Grant Support
Reg. No./Substance:
7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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