| Intravenous nicardipine for the treatment of severe hypertension. A double-blind, placebo-controlled multicenter trial. | |
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MedLine Citation:
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PMID: 2688586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A placebo-controlled, double-blind multicenter trial was conducted in 123 patients with severe hypertension to examine the efficacy and safety of intravenously administered nicardipine hydrochloride in controlling blood pressure. Seventy-three patients were initially randomized to receive nicardipine treatment. This group had an initial blood pressure of 213 +/- 3/126 +/- 2 mm Hg. Sixty-seven patients achieved the therapeutic goal (diastolic blood pressure less than or equal to 95 mm Hg; systolic blood pressure less than or equal to 160 mm Hg). Fifty patients were randomized to receive placebo solution. Blood pressure in these patients was 216 +/- 3/125 +/- 2 mm Hg. No patient in this group achieved the therapeutic goal during the "blinded" portion of the study. Forty-four of 49 patients who did not respond to placebo administration responded to subsequent treatment with nicardipine. Patients with end-organ damage were included in the study. These included patients with left ventricular hypertrophy, retinopathy, and renal insufficiency. Patients with and without end-organ damage responded equally well to nicardipine treatment. Serious adverse experiences were infrequent, the most common adverse reaction being headache in 24% of the patients studied. |
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Authors:
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J D Wallin; E Fletcher; C V Ram; M E Cook; D G Cheung; E P MacCarthy; R Townsend; E Saunders; W R Davis; H G Langford |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Archives of internal medicine Volume: 149 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1990-01-12 Completed Date: 1990-01-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2662-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Nephrology, Tulane University Medical School, New Orleans, La. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dose-Response Relationship, Drug Double-Blind Method Female Follow-Up Studies Headache / chemically induced Humans Hypertension / drug therapy*, physiopathology Hypotension / chemically induced Infusions, Intravenous Kidney / physiopathology Male Middle Aged Multicenter Studies as Topic Nicardipine / adverse effects, blood, therapeutic use* Placebos |
| Chemical | |
Reg. No./Substance:
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0/Placebos; 55985-32-5/Nicardipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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