Document Detail


Intravenous metronidazole in the newborn.
MedLine Citation:
PMID:  6870333     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty four neonates at high risk of anaerobic sepsis were treated with intravenous metronidazole, 7.5 mg/kg, 8 hourly, for a mean period of 5 days. The highest observed concentration after the first dose (mean +/- SD) 9.6 +/- 4.0 mg/l (56.1 +/- 23.4 mumol/l) was significantly lower (P less than 0.001) than the highest observed concentration after the final dose (mean +/- SD) 19.3 +/- 8.6 mg/l (112.7 +/- 50.2 mumol/l). The overall metronidazole half life was (mean +/- SD) 23.4 +/- 13.1 hours. The half life after the first dose (mean +/- SD) 21.9 +/- 10.1 hours was not appreciably different from the half life after the final dose (mean +/- SD) 21.6 +/- 12.4 hours. The concentrations of the major metabolite of metronidazole (20396RP) also rose appreciably during treatment. No side effects of metronidazole were noted and its extended half life in neonates suggests that less frequent dosage would be appropriate.
Authors:
P Hall; C M Kaye; N McIntosh; J Steele
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  58     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-08-26     Completed Date:  1983-08-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  529-31     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Bacterial Infections / prevention & control
Female
Half-Life
Humans
Infant, Low Birth Weight
Infant, Newborn*
Infant, Newborn, Diseases / prevention & control
Infant, Premature
Injections, Intravenous
Kinetics
Metronidazole / administration & dosage,  analogs & derivatives,  blood*
Chemical
Reg. No./Substance:
443-48-1/Metronidazole; 4812-40-2/1-(2-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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