Document Detail

Intravenous lorazepam as an amnestic and anxiolytic agent in the intensive care unit: a prospective study.
MedLine Citation:
PMID:  8045144     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the efficacy and hemodynamic safety of intravenous lorazepam as an amnestic and anxiolytic agent in patients undergoing critical care procedures. DESIGN: Prospective study. SETTING: Trauma/intensive care unit and coronary care unit of a 524-bed, tertiary, teaching community hospital. SUBJECTS: Ten patients undergoing critical care procedures. INTERVENTIONS: Intravenous lorazepam was administered at an initial dose of 2 mg, 15 to 20 mins before the critical care procedure (procedures included both invasive and noninvasive techniques) was performed. Anxiety level and memory assessment were evaluated at baseline and at various points following lorazepam administration. Changes in hemodynamic status were evaluated regularly throughout the study. MEASUREMENTS AND MAIN RESULTS: No significant changes in hemodynamic measurements were observed after administration of intravenous lorazepam. Significant differences were seen in anxiety scores and amnestic effects from preprocedure/pre-lorazepam to post-lorazepam evaluations (all p values were < .03). CONCLUSIONS: This study confirms the beneficial anxiolytic and amnestic effects of lorazepam in a subgroup of patients undergoing critical care procedures. The study also substantiates the safety of this drug in this patient population.
S A Deppe; M E Sipperly; A I Sargent; R J Kuwik; D R Thompson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  22     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-09-01     Completed Date:  1994-09-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1248-52     Citation Subset:  AIM; IM    
Department of Medicine, Mercy Hospital of Pittsburgh, PA 15219.
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MeSH Terms
Aged, 80 and over
Amnesia, Retrograde / chemically induced*,  diagnosis,  physiopathology
Anxiety / diagnosis,  drug therapy*,  etiology,  physiopathology
Catheterization, Central Venous / adverse effects*,  psychology*
Catheterization, Peripheral / adverse effects*,  psychology*
Conscious Sedation / methods*
Critical Care*
Hemodynamics / drug effects*
Infusions, Intravenous
Lorazepam / pharmacology,  therapeutic use*
Memory / drug effects*
Middle Aged
Premedication / methods*
Prospective Studies
Severity of Illness Index
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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