| Intravenous lipopolysaccharide-induced pulmonary maturation and structural changes in fetal sheep. | |
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MedLine Citation:
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PMID: 19110233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Antenatal pulmonary inflammation is associated with reduced risk for respiratory distress syndrome but with an increased risk for bronchopulmonary dysplasia (BPD) with impaired alveogenesis. OBJECTIVE: We hypothesized that fetal systemic inflammation induced by intravenous (IV) lipopolysaccharide (LPS) would affect lung development in utero. STUDY DESIGN: Twenty-one fetal sheep were instrumented (107 days gestational age). Control fetuses received saline (N = 12) and 9 in the study group received 100 ng of LPS IV 3 days after surgery. Animals were assessed for lung maturation and structure after 3 (N = 5) and 7 (N = 4) days. RESULTS: Interleukin-6 concentration increased in the bronchoalveolar lavage more than 40-fold 3 days after LPS IV. Processing of pro-surfactant protein (SP)-B to mature SP-B and increased SP-B concentrations were shown 7 days after LPS IV. Deposition of elastin fibers at sites of septation was disturbed within 3 days after LPS IV. CONCLUSION: Lung maturation and disturbed lung structure occurred after short-term exposure to fetal inflammation and suggests new targeted therapies for BPD. |
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Authors:
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Boris W Kramer; Andreas Ladenburger; Steffen Kunzmann; Christian P Speer; Jasper V Been; J Freek van Iwaarden; Luc J I Zimmermann; Markus Gantert; Yves Garnier |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-25 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 200 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-02 Completed Date: 2009-02-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 195.e1-10 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Maastricht University Hospital Center, the Netherlands. bkra@paed.azm.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Proliferation Elastin / immunology Female Fetal Diseases / immunology* Fetal Organ Maturity / immunology* Fetus Lipopolysaccharides / administration & dosage* Lung / growth & development, immunology* Lung Compliance Lung Diseases / immunology* Pulmonary Surfactant-Associated Protein B / immunology Sheep |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides; 0/Pulmonary Surfactant-Associated Protein B; 9007-58-3/Elastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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