Document Detail

Intravenous labetalol in the treatment of severe hypertension.
MedLine Citation:
PMID:  7093105     Owner:  NLM     Status:  MEDLINE    
1 We have compared, in patients with severe hypertension, the administration of intravenous labetalol by single rapid injection, by repeated bolus injections, and by incremental infusion. 2 Incremental infusion was the most consistently (albeit not invariably) effective method, and that least prone to cause side-effects. 3 An occasional very marked decrease in blood pressure was seen with all these techniques but least often with incremental infusion. Thus close and continuous supervision is mandatory. 4 All three methods produced slight but significant decreases in heart rate, and in plasma angiotensin II and aldosterone. 5 Intravenous labetalol was also effective in controlling hypertensive crises of phaeochromocytoma and those following the withdrawal of clonidine. 6 In a total of 70 severely hypertensive patients given intravenous labetalol, none showed adverse neurological or cardiological sequelae.
A M Cumming; J J Brown; A F Lever; J I Robertson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  13     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-09-17     Completed Date:  1982-09-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  93S-96S     Citation Subset:  IM    
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MeSH Terms
Adrenal Gland Neoplasms / complications
Catecholamines / blood
Clonidine / adverse effects
Ethanolamines / administration & dosage*
Hypertension / drug therapy*
Infusions, Parenteral
Injections, Intravenous
Labetalol / administration & dosage*
Pheochromocytoma / complications
Substance Withdrawal Syndrome / drug therapy
Reg. No./Substance:
0/Catecholamines; 0/Ethanolamines; 36894-69-6/Labetalol; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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