Document Detail


Intravenous labetalol in the treatment of severe hypertension.
MedLine Citation:
PMID:  7093105     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1 We have compared, in patients with severe hypertension, the administration of intravenous labetalol by single rapid injection, by repeated bolus injections, and by incremental infusion. 2 Incremental infusion was the most consistently (albeit not invariably) effective method, and that least prone to cause side-effects. 3 An occasional very marked decrease in blood pressure was seen with all these techniques but least often with incremental infusion. Thus close and continuous supervision is mandatory. 4 All three methods produced slight but significant decreases in heart rate, and in plasma angiotensin II and aldosterone. 5 Intravenous labetalol was also effective in controlling hypertensive crises of phaeochromocytoma and those following the withdrawal of clonidine. 6 In a total of 70 severely hypertensive patients given intravenous labetalol, none showed adverse neurological or cardiological sequelae.
Authors:
A M Cumming; J J Brown; A F Lever; J I Robertson
Related Documents :
891615 - Changes in rat hind limb vascular resistance following intracerebroventricular drug adm...
10551595 - Antinociceptive and hemodynamic effects of a novel alpha2-adrenergic agonist, mpv-2426,...
1167185 - Suppression of antidiuretic hormone secretion by clonidine in the anesthetized dog.
8069405 - Expression of beta-adrenoceptors on circulating mononuclear cells in hypertensives and ...
8325575 - Intralaryngeal pressure conditions and a membranophonic interpretation of voice product...
18695105 - Determinants of the optic cup to disc ratio in an asian population: the singapore malay...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  13     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-09-17     Completed Date:  1982-09-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  93S-96S     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenal Gland Neoplasms / complications
Catecholamines / blood
Clonidine / adverse effects
Ethanolamines / administration & dosage*
Humans
Hypertension / drug therapy*
Infusions, Parenteral
Injections, Intravenous
Labetalol / administration & dosage*
Pheochromocytoma / complications
Substance Withdrawal Syndrome / drug therapy
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Ethanolamines; 36894-69-6/Labetalol; 4205-90-7/Clonidine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The acute and chronic hypotensive effect of labetalol and the relationship with pretreatment plasma ...
Next Document:  Intravenous labetalol in severe hypertension.