Document Detail


Intravenous labetalol in the management of severe hypertension and hypertensive emergencies.
MedLine Citation:
PMID:  6720529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intravenous administration of labetalol, a combined alpha- and beta-adrenergic receptor blocking agent, reduced diastolic blood pressure by 30 mm Hg or more in 15 of 17 patients with severe hypertension (supine diastolic blood pressure greater than or equal to 125 mm Hg). A method repeated intravenous injection of the drug produced a prompt but gradual reduction of arterial blood pressure without the induction of a reflex tachycardia. Side effects were mild and of brief duration despite the presence of hypertensive complications in many of these patients. Hypotension, coronary insufficiency, or neurologic deterioration did not occur. Labetalol appears to be a suitable alternative to the direct vasodilating agents in the management of patients with severe hypertension and hypertensive emergencies.
Authors:
M D Cressman; D G Vidt; R W Gifford; W S Moore; D J Wilson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  107     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-06-01     Completed Date:  1984-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  980-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Blood Pressure / drug effects
Diazoxide / therapeutic use
Ethanolamines / therapeutic use*
Female
Humans
Hypertension / complications,  drug therapy*
Injections, Intravenous
Labetalol / adverse effects,  therapeutic use*
Male
Middle Aged
Nitroprusside / therapeutic use
Pulse / drug effects
Chemical
Reg. No./Substance:
0/Ethanolamines; 15078-28-1/Nitroprusside; 364-98-7/Diazoxide; 36894-69-6/Labetalol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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